W04_08 Fever

Question 1

normal body temp depends on time of day

Answer 1

okay

Question 2

diurnal variation of body temp depends on the sleep-wake cycle

Answer 2

okay.

Question 3

where’s the most consistent body part to measure temperature?

Answer 3

axilla. (oral is least consistent)

Question 4

what’s the definition of fever?

Answer 4

AM > 37.2;
PM > 37.7;
just monitor closely at 37.8

Question 5

definition of febrile neutropenia?

Answer 5

low WBC +
T ≥ 38.3 once orally, or
≥38.0 for 1 hour

Question 6

definition of fever of unknown origin

Answer 6

fever ≥38.3 on multiple readings over 3 weeks, and no cause after initial standard investigations and not FN, HIV, HSCT/SOT, nosocomial acquisition

Question 7

which organ regulates body temp?

Answer 7

hypothalamus

Question 8

what cytokine across the BBB causes increased hypothalamus temp set point?

Answer 8

PGE2

Question 9

no adverse effects of fever <41C has been shown in adults

Answer 9

although children may develop seizures with T>39.

Question 10

what are other causes of elevated body temp that’s not fever?

Answer 10

hyperthermia;

hyperpyrexia (T>41)

Question 11

note: means of fever is the same as to those used when the body is cold

Answer 11

feeling of chills, shivering, burning brown fat

Question 12

how do anti-pyretics work?

Answer 12

block COX from converting arachidonic acid into PGE

Question 13

what are common anti-pyretics?

Answer 13

asa, tylenol, ibuprofen, naproxen

Question 14

don’t use anti-pyretics for hyperthermia

Answer 14

it’s not due to COX enzymes