W03_06 immunodeficiency III

Question 1

what is hypogammaglobulinemia?

Answer 1

deficiency in ALL Igs

Question 2

what is dysgammaglobulinemia?

Answer 2

deficiency in SOME Igs

Question 3

name examples of acquired causes of immunoglobulin deficiency

Answer 3

nephrotic syndrome;
malabsorption/protein-losing enteropathy (GI);
chronic lymphocytic leukemia (CLL)

Question 4

what is spontaneous bacterial peritonitis?

Answer 4

leaky vasculature in gut allows gut biome into the ascitic peritoneum

Question 5

what kinds of illnesses does Ig deficiency cause?

Answer 5

sinopulmonary, GI, skin infections

Question 6

how to recognize functional asplenia histologically?

Answer 6

howell-jolly bodies and heinz bodies

Question 7

what’s a howell-jolly body?

Answer 7

remnant of nucleus in the RBC; sign of asplenia

Question 8

what’s a heinz body?

Answer 8

clumps denatured hemoglobin in RBCs; sign of asplenia

Question 9

what is OPSI?

Answer 9

overwhelming post-splenectomy infection

Question 10

what is capnocytophage canimorsus?

Answer 10

infection from dog bite - higher risk after asplenia

Question 11

what are the major infections of a patient with asplenia?

Answer 11

streptococcus pneumoniae and nesserie meningitidis

Question 12

HPV oncogenesis can cause which type of cancers?

Answer 12

oesophageal, cervical, anal