W03_01 type 1 immediate hypersensitivity Flashcards
do genetics play a role in asthma?
yes; strong risk factor
what does atopic mean?
developing an allergic reaction in a place not in contact with the allergen
children with atopic dermatitis are at increased risk of what?
asthma
what’s the hygiene hypothesis?
children are born with Th2 predisposition and are supposed to move towards Th1 (bacterial; IL-2, TNF) as they play in the world. If they’re too clean, they stay at Th2 and will develop allergies.
how does diet affect allergy development?
fresh fruit + veggies = more anti-oxidants;
fatty acids can shift to allergies;
food preservatives can affect flora and develop allergies instead of tolerance
how do proton pump inhibitors affect allergies?
less acid, so incomplete food breakdown into potentialallergens
what are three types of immediate hypersensitivity?
immunologic, IgE-mediated
immunologic, non-IgE-mediated
non-immunologic
how does theimmunologic, non-IgE mediated pathway work?
random things trigger mast cell activation. Complement involved.
name examples of non-IgE mediated pathway inducers
muscle relaxants, antibiotics, radio contrast agents, protamine, ASA, NSAIDs
which mediators change B cells to IgE-producing?
CD40, IL-4
which cell types does IgE bind to to sensitize?
mast cells
basophils
which receptor binds IgE?
Fc epsilon R1
what were the two main types of mast cells discussed in class? (hint: tissue types)
connective tissue and mucosal
what’s the difference ofmast cell granule contents and newly formed mediators on theimmune reaction?
newly formed mediators (prostaglandins, leukotrienes) cause severe symptoms
what are the 3 types of mediators form mast cells?
preformed, granule contents;
newly formed, leukotrienes, prostaglandins, PAF;
cytokines, TNF, IL3, IL4, IL5, IL13, etc
