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Microbiology Exam #1 > VZV, EBV, CMV, Herpes 4-8 > Flashcards

VZV, EBV, CMV, Herpes 4-8 Flashcards

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Biology 101 flashcards
1
Q

Common name for varicella?

A

Chicken Pox

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2
Q

CP is result of ______ infection of VZV

A

Primary

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3
Q

Symptoms of Varicella

A

Vesicles, Pustule, Crust, Scabbed Lesions
Spreads of entire body, but mostly trunk
Presence on scalp is unique

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4
Q

Potential side effect of adult chicken pox?

A

Interstitial pneumonia

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5
Q

Common name for herpes zoster?

A

Shingles

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6
Q

Where does shingles come from?

A

Latent varicella infection

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7
Q

Clinical presentation of shingles?

A

Painful, Unilateral vesicular rash

Blisters follow dermatomes

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8
Q

VSV pathogenesis?

A

Inf. respiratory tract
reticuloendothelial system
viremia
Latent in DRG/CN Ganglia

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9
Q

Epstein Barr genome?

A

dsDNA

icosahedral capsid

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10
Q

How does EBV replicate?

A

Attach of Bcells and nasopharyngeal epithelium

Internalize via cytoplasmic vesicles

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11
Q

Three potential EBV infection outcomes?

A

Replication in B cells
Latent B cell infection (esp. with T cells around)
Stimulate and immortalize B cells

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12
Q

Non-permissive B cell infection genes produced?

A

Epstein Barr Antigens
Latent Membrane Proteins
Latent Proteins

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13
Q

What do EBNAs and LPs do?

A

DNA binding proteins for establishing infection

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14
Q

What do LMPs do?

A

Membrane proteins with oncogene like activity

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15
Q

What genes are expressed in latent memory B cells?

A

EBNA and LMP

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16
Q

Infection associated with Permissive epit. and B cell EBV?

A

heterophile Antibody Positive Infectious Mononucleosis

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17
Q

Symptoms of eterophile Antibody Positive Infectious Mononucleosis

A

Lymphodenopathy, Splenomegaly, Exudative pharyngitis

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18
Q

What is HBV-Induced Lymphoproliferative Disease?

A

Lymphocytes produced in excessive quantities
Lack of T cell Immunity
Occurs in BM, Kidney, Liver, Heart, Lung transplant

19
Q

What is Burkitt’s lymphoma?

A

Agressive B cell Lymphoma of the jaw/face
Poorly differentiated B cells
Usually children
Associated with HIV

20
Q

Describe nasopharyngeal carcinoma.

A 
Cancer of nasopharynx
Endemic in Asia/N Africa
Adults
Epithelial Cells
Nasal Discharge/Bleeding, Ear Infections, Metastasis
21
Q

Pathogenesis of EBV

A

Transmitted by saliva
Acute – Vermia and infection of lymphoreticular
Latent – Presents in B cell and epithelial cells

22
Q

What is a Downey Cell?

A

Atypical T-cell

Abundant pale cytoplasm, basophilic cytoplasm, insinuation btw RBCs

23
Q

In adults, how can you detect EBV infection?

A

Heterophile Antibody

24
Q

Important knowledge for EBV recovery?

A

Avoid Spleen Trauma

25
Q

CMV full name?

A

betaherpesvirinae

26
Q

Types of CMV infection?

A

Congenital Infection

Heterophile-negative mononucleosis

27
Q

Clinical Presentation of Congenital CMV?

A

Primary inf. of pregnant mother spread via placenta

Most babies born have no CMV symptoms

28
Q

Possible CMV symptoms

A

Liver+spleen+lung ploblems, Seizures
hearing/Vision Loss, Mental Disability
Seizures, Death

29
Q

Heterophile-negative mononucleosis test result?

A

Negative Paul-Bunell Test

30
Q

CMV symptoms in AIDS patients?

A

Pneumonia, Gastroenteritis, Retinitis, Encephalitis

31
Q

Pathogenesis of CMV?

A

Replic. in Salivary Glands and Kidneys
Produces Cowdry Type A cells
Persistent salivary infection, breasts, kidneys

32
Q

CMV classic sign

A

Owl’s Eye seen in lung section

33
Q

How to get rid of CMV?

A

You don’t.

34
Q

Drugs used against CMV?

A

Gancyclovir
Valganciclovir
Foscarnet
Cidofovir

35
Q

Herpes 6 and 7 infects what cell types?

A

Lymphocytes, Monocytes, Epithelial, and endothelial cells

36
Q

Where does Herpes 6 and 7 replicate?

A

Salivary glands

37
Q

Common infection caused by Herpes 6 and 7?

A

Roseola

38
Q

What is Roseola?

A

Common, Mild, Febrile disease of infant

39
Q

Clinical presentation of Herpes 6 and 7 in adults?

A

Encephalitis, Lymphodenopahthy, Hepatitis

40
Q

Herpes Virus 8 is associated with….

A

Kaposi’s sarcoma

41
Q

Primary target of Herpes Virus 8?

A

B cells

42
Q

What is Kaposi’s Sarcoma?

A

Spindle cell tumor, endothelial lineage
Patches of abnormal tissue grown under skin/in mucosa
Red/Purple Color
Can spread to GI or lungs – Bleeding

43
Q

Herpes Virus 8 is especially prevalent in what population?

A

Gay/Bisexual Men and Africans

Microbiology Exam #1 (27 decks)

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