VZV, EBV, CMV, Herpes 4-8 Flashcards
Common name for varicella?
Chicken Pox
CP is result of ______ infection of VZV
Primary
Symptoms of Varicella
Vesicles, Pustule, Crust, Scabbed Lesions
Spreads of entire body, but mostly trunk
Presence on scalp is unique
Potential side effect of adult chicken pox?
Interstitial pneumonia
Common name for herpes zoster?
Shingles
Where does shingles come from?
Latent varicella infection
Clinical presentation of shingles?
Painful, Unilateral vesicular rash
Blisters follow dermatomes
VSV pathogenesis?
Inf. respiratory tract
reticuloendothelial system
viremia
Latent in DRG/CN Ganglia
Epstein Barr genome?
dsDNA
icosahedral capsid
How does EBV replicate?
Attach of Bcells and nasopharyngeal epithelium
Internalize via cytoplasmic vesicles
Three potential EBV infection outcomes?
Replication in B cells
Latent B cell infection (esp. with T cells around)
Stimulate and immortalize B cells
Non-permissive B cell infection genes produced?
Epstein Barr Antigens
Latent Membrane Proteins
Latent Proteins
What do EBNAs and LPs do?
DNA binding proteins for establishing infection
What do LMPs do?
Membrane proteins with oncogene like activity
What genes are expressed in latent memory B cells?
EBNA and LMP
Infection associated with Permissive epit. and B cell EBV?
heterophile Antibody Positive Infectious Mononucleosis
Symptoms of eterophile Antibody Positive Infectious Mononucleosis
Lymphodenopathy, Splenomegaly, Exudative pharyngitis
What is HBV-Induced Lymphoproliferative Disease?
Lymphocytes produced in excessive quantities
Lack of T cell Immunity
Occurs in BM, Kidney, Liver, Heart, Lung transplant
What is Burkitt’s lymphoma?
Agressive B cell Lymphoma of the jaw/face
Poorly differentiated B cells
Usually children
Associated with HIV
Describe nasopharyngeal carcinoma.
Cancer of nasopharynx Endemic in Asia/N Africa Adults Epithelial Cells Nasal Discharge/Bleeding, Ear Infections, Metastasis
Pathogenesis of EBV
Transmitted by saliva
Acute – Vermia and infection of lymphoreticular
Latent – Presents in B cell and epithelial cells
What is a Downey Cell?
Atypical T-cell
Abundant pale cytoplasm, basophilic cytoplasm, insinuation btw RBCs
In adults, how can you detect EBV infection?
Heterophile Antibody
Important knowledge for EBV recovery?
Avoid Spleen Trauma
CMV full name?
betaherpesvirinae
Types of CMV infection?
Congenital Infection
Heterophile-negative mononucleosis
Clinical Presentation of Congenital CMV?
Primary inf. of pregnant mother spread via placenta
Most babies born have no CMV symptoms
Possible CMV symptoms
Liver+spleen+lung ploblems, Seizures
hearing/Vision Loss, Mental Disability
Seizures, Death
Heterophile-negative mononucleosis test result?
Negative Paul-Bunell Test
CMV symptoms in AIDS patients?
Pneumonia, Gastroenteritis, Retinitis, Encephalitis
Pathogenesis of CMV?
Replic. in Salivary Glands and Kidneys
Produces Cowdry Type A cells
Persistent salivary infection, breasts, kidneys
CMV classic sign
Owl’s Eye seen in lung section
How to get rid of CMV?
You don’t.
Drugs used against CMV?
Gancyclovir
Valganciclovir
Foscarnet
Cidofovir
Herpes 6 and 7 infects what cell types?
Lymphocytes, Monocytes, Epithelial, and endothelial cells
Where does Herpes 6 and 7 replicate?
Salivary glands
Common infection caused by Herpes 6 and 7?
Roseola
What is Roseola?
Common, Mild, Febrile disease of infant
Clinical presentation of Herpes 6 and 7 in adults?
Encephalitis, Lymphodenopahthy, Hepatitis
Herpes Virus 8 is associated with….
Kaposi’s sarcoma
Primary target of Herpes Virus 8?
B cells
What is Kaposi’s Sarcoma?
Spindle cell tumor, endothelial lineage
Patches of abnormal tissue grown under skin/in mucosa
Red/Purple Color
Can spread to GI or lungs – Bleeding
Herpes Virus 8 is especially prevalent in what population?
Gay/Bisexual Men and Africans
