Adenoviruses

Question 1

Adenoviruses have what kind of DNA?

Answer 1

Linear, Double-stranded

Question 2

What type of caspid does it have?

Answer 2

Icosahedral

Question 3

Does the virus have an envelope?

Answer 3

No

Question 4

What are the fibers with antigen specificity called?

Answer 4

Hemagglutinin

Question 5

Adeno is the only virus with….

Answer 5

A fiber in every vertices

Question 6

Most of the body of the adenovirus is comprised of…

Answer 6

Hexon

Question 7

How does adeno bind?

Answer 7

Attachment to the Coxsackie/Adenovirus Receptor

Interactions between the base and av integrins lead to internalization.

Question 8

Where does transcription/replication occur?

Answer 8

Nucleus of Infected Cell

Question 9

What divides early and late DNA replication?

Answer 9

Viral DNA replication

Question 10

What are immediate early genes? Name two in adeno.

Answer 10

Protein products needed for DNA synthesism altered host cell genes, and late gene transcription.

E1A and E1B

Question 11

How does adeno present?

Answer 11

Respiratory tract diseases -- ARS
Ocular Diseases -- Pharyngoconjunctival fever, epidemic keratoconjunctivitis
Acute Hemorrhagic Cystitis
Gastroenteritis
Inf. in immunocompromised

Question 12

Acute respiratory disease is caused by which adenos?

Answer 12

Types 1, 2, 5, and 6

Question 13

Symptoms of Acute Respiratory Disease?

Answer 13

Fever, Runny Nose, Cough, Sore Throat for 3-5 days
50% of cases – prolonged fever, leukocytosis
Bronchitis, Pneumonia, Conjunctivitis

Question 14

Fatal pneumonia is associated with what serotypes?

Answer 14

3, 7, 14, 21, 30

Question 15

What serotype is “Super Cold”

Answer 15

14

Question 16

What is pharyngoconjunctival fever?

Answer 16

Fever, Sore Throat, Corysa, red eyes.

May or may not have respiratory symptoms. Mya be one or both eyes.

Question 17

Which Adeno strains make pharyngoconjunctival fever?

Answer 17

3, 4, and 7

Question 18

What is epidemic keratoconjunctivitis?

Answer 18

highly contagious, bilateral palpebral, follicular conjunctivitis with keratitis. Inflammation can last for weeks, scarring and visual impairment may follow.

Question 19

What adeno serotypes are associated with epidemic keratoconjunctivitis?

Answer 19

8, 19, 37

Question 20

What is acute hemorrhagic cystitis?

Answer 20

Increased frequency, pain, and bloody urine

Question 21

What serotypes are associated with acute hemorrhagic cystitis?

Answer 21

11 and 21

Question 22

Symptoms of gastroenteritis

Answer 22

Common cause of infantile diarrhea in the daycare center

Fever

Question 23

Which adeno serotypes are associated with enteritis?

Answer 23

40 and 42

Question 24

What might cause a patient to be immunocompromised?

Answer 24

SC Transplant, T cell depletion, high dose Ab therapy, immunosuppresion

Question 25

How might adeno present in an immunocompromised patient?

Answer 25

Hemorrhagic cysts, pneumonitis, hepatitis, gastroent., nephritis

Question 26

Who is adeno transmitted?

Answer 26

Droplet inhalation, fecal-oral route

Question 27

Types of infections caused by adeno?

Answer 27

Lytic infection, Latent infection

Question 28

Relationship between Adeno and cancer?

Answer 28

Viral DNA integration can cause oncogenic transformation

Question 29

What groups are most at risk for adeno?

Answer 29

Children Under 14

People in Crowded Areas

Question 30

What group commonly suffers adeno outbreaks?

Answer 30

Military recruits

Question 31

How is Adeno controlled?

Answer 31

Prevention by vaccine