Adenoviruses Flashcards
Adenoviruses have what kind of DNA?
Linear, Double-stranded
What type of caspid does it have?
Icosahedral
Does the virus have an envelope?
No
What are the fibers with antigen specificity called?
Hemagglutinin
Adeno is the only virus with….
A fiber in every vertices
Most of the body of the adenovirus is comprised of…
Hexon
How does adeno bind?
Attachment to the Coxsackie/Adenovirus Receptor
Interactions between the base and av integrins lead to internalization.
Where does transcription/replication occur?
Nucleus of Infected Cell
What divides early and late DNA replication?
Viral DNA replication
What are immediate early genes? Name two in adeno.
Protein products needed for DNA synthesism altered host cell genes, and late gene transcription.
E1A and E1B
How does adeno present?
Respiratory tract diseases -- ARS Ocular Diseases -- Pharyngoconjunctival fever, epidemic keratoconjunctivitis Acute Hemorrhagic Cystitis Gastroenteritis Inf. in immunocompromised
Acute respiratory disease is caused by which adenos?
Types 1, 2, 5, and 6
Symptoms of Acute Respiratory Disease?
Fever, Runny Nose, Cough, Sore Throat for 3-5 days
50% of cases – prolonged fever, leukocytosis
Bronchitis, Pneumonia, Conjunctivitis
Fatal pneumonia is associated with what serotypes?
3, 7, 14, 21, 30
What serotype is “Super Cold”
14
What is pharyngoconjunctival fever?
Fever, Sore Throat, Corysa, red eyes.
May or may not have respiratory symptoms. Mya be one or both eyes.
Which Adeno strains make pharyngoconjunctival fever?
3, 4, and 7
What is epidemic keratoconjunctivitis?
highly contagious, bilateral palpebral, follicular conjunctivitis with keratitis. Inflammation can last for weeks, scarring and visual impairment may follow.
What adeno serotypes are associated with epidemic keratoconjunctivitis?
8, 19, 37
What is acute hemorrhagic cystitis?
Increased frequency, pain, and bloody urine
What serotypes are associated with acute hemorrhagic cystitis?
11 and 21
Symptoms of gastroenteritis
Common cause of infantile diarrhea in the daycare center
Fever
Which adeno serotypes are associated with enteritis?
40 and 42
What might cause a patient to be immunocompromised?
SC Transplant, T cell depletion, high dose Ab therapy, immunosuppresion
How might adeno present in an immunocompromised patient?
Hemorrhagic cysts, pneumonitis, hepatitis, gastroent., nephritis
Who is adeno transmitted?
Droplet inhalation, fecal-oral route
Types of infections caused by adeno?
Lytic infection, Latent infection
Relationship between Adeno and cancer?
Viral DNA integration can cause oncogenic transformation
What groups are most at risk for adeno?
Children Under 14
People in Crowded Areas
What group commonly suffers adeno outbreaks?
Military recruits
How is Adeno controlled?
Prevention by vaccine
