Herpes Virus - HSV 1 and HSV 2 Flashcards

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1
Q

Genome?

A

dsDNA

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2
Q

Reservoir?

A

Humans

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3
Q

Where does the envelope come from?

A

Nucleus

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4
Q

Alpha-Herpes includes what viruses?

A

Herpes Simplex 1 and 2

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5
Q

HSV encodes what enzymes?

A

DNA-dependent DNA pol

Thymidine Kinase

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6
Q

Clinical presentation of HSV?

A

Usually asymptomatic

Both can cause oral and genital infections

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7
Q

Two types of oral herpes?

A

Acute Herpetic gingivostomatitis

Cold Sores/Herpes Labialis

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8
Q

Symptoms of Acute Herpetic gingivostomatitis

A

Clear lesions, then white-ish ulcers
Covers mouth, pharynx
Discomfort, fever, gingivitis, lymphendectomy, difficulty speaking/eating

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9
Q

What age group usually gets Acute Herpetic gingivostomatitis?

A

Kids 1-4

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10
Q

What herpes usually causes oral herpes?

A

HSV-1

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11
Q

Describe cold sores.

A

Vesicles, Ulceration, Inflammation, Edema

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12
Q

What is herpes keratitis? Which virus usually?

A

Herpes of the eye, HSV-1

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13
Q

Clinical presentation of herpes keratitis?

A

Unilateral Red Eye, Pain, Photophobia
Dendritic Corneal Ulcer
Most frequent cause of blindness.

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14
Q

What is herpes whitlow?

A

Herpes of small wounds of hands/wrist through secretions

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15
Q

Clinical presentation of herpes whitlow?

A

Pain and Burning, Erythema, Edema, Vesicles, Fever

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16
Q

What is herpes gladitorum?

A

Clusters of blisters seen on head/neck that are common among contact sports

17
Q

What is eczema herpeticum?

A

Rare, pediatric infection at sites of skin damage by eczema/dermatitis

18
Q

Typical virus to cause genital herpes?

A

HSV-2

19
Q

Symptoms of genital herpes?

A

Small red bumps, blisters, open sores
Pain/Itching
Flu-like symptoms

20
Q

Typical virus to cause HSV encephalitis?

A

HSV-1

21
Q

HSV encephalitis claim to fame?

A

Most common viral encephalitis

22
Q

Clinical presentation of HSV encephalitis?

A

Early - Fever, headache, Nausea

Late - Encephalopathy (lethargy, confusion, delirium)

23
Q

What part of the brain is typically targeted?

A

Temporal Lobes

24
Q

What is seen in CSF on HSV encephalitis

A

Elevated Proteins, WBC
Low Glucose
RBC from hemorhage

25
Q

Most common viral cause of HSV meningitis?

A

HSV-2

26
Q

HSV Meningitis is often a complication of…

A

genital herpes

27
Q

Most common viral source of neonatal herpes?

A

HSV-2

28
Q

How is neonatal herpes transferred?

A

During delivery through infected maternal genital tract
Transplacental
Hospital Acquired

29
Q

Post-birth neonatal herpes symptoms?

A

Usually on skin, eyes, mouth

Encephalitis is common

30
Q

Pre-birth neonatal herpes symptoms?

A

Premature birth, low birth-weight

Microcephaly, hydrocephalus, chorioretinitis

31
Q

Easy way to guess which HSV it is?

A
HSV-1 = above the waist
HSV-2 = Below the waist
32
Q

Pathogenesis?

A

Establishes latent infection in sensory ganglia

Upon reactivation, spreads out from ganglion to make lesions

33
Q

What is cowdry type A?

A

Intranuclear eosinophilic amorphous

droplet like bodies surrounded by clear halo

34
Q

Virus is transmitted through…

A

Saliva, vaginal secretions, lesion fluids

35
Q

Control of Herpes?

A

Cyclovirs
Arabinoside
Iododeoxyuridine
Trifluridine