Filoviridae -- Ebola + Marburg

Question 1

Describe filoviridae genome.

Answer 1

-ssRNA
Helical Capsid
Enveloped

Question 2

Common symptoms of flavi viruses?

Answer 2

Damaged microvasculature
Increased Permeability
Severe/Fatal Hemorrhage

Question 3

Clinical Presentation?

Answer 3

Hemorrhagic Fever
First – Flu-like, Diarrhea
Next – Nausea, Vomiting, Ab Pain, Chest Pain, Shortness of Breath, Edema
Later – Mucosal Hemorrhage, Rash, Brain Damage

Question 4

Common cause of death?

Answer 4

Metabolic Disturbances and Shock

Question 5

Transmission? Reservoir?

Answer 5

Uncertain. Maybe bats?

Question 6

Transmission in Humans?

Answer 6

Direct contact with infected body fluids

Question 7

Common characteristic of Ebola Infection –

Answer 7

Destruction of Immune System

Question 8

The problem of Ebola/Immune relations

Answer 8

Ebola infects monocytes/macrophages, releases cyto.
Stimulates loss of vascular integrity
Hemmorhage and vasomotor collapse

Question 9

What is Marburg virus?

Answer 9

Similar virus that had an outbreak in Germany with infected lab apes.