Arbovirus -- Flaviviruses -- Hemorrhagic Fever Viruses Flashcards
Name the Dengue Fever serotypes.
DENV-1, DENV-2, DENV-3, DENV-4
Clinical Presentation of Dengue Fever
First exposure – usually nothing/mild symp.
If symptomatic – High, Saddleback fever, Headache, muscle/joint pain, pain behind eyes, rash, nausea, gum bleeding
Who is most likely to get Dengue Hemorrhagic Fever?
Subjects under 15 years
Presentation of Dengue Hemm. Fever?
Initially like Dengue Fever
1 day later – plasma leakage, GI bleeding, hematuria, ab pain, seizures
Cause of Dengue Shock Syndrome?
Untreated Dengue Hemorrhagic Fever
Presentation of Dengue Shock Syndrome?
Ab pain, vomiting, restlessness
Circulatory Failure
Path. of Dengue.
Virus –> Langerhans cells
Presented to T Cells
Viruses enter monocyte/endothelial cells, attacked by lymphocytes
Excess cytokine release –> leakage of plasma
Water/Proteins Escape to extravascular space –> hypovolemic shock
Why are second Dengue infections worse?
Second time around virus is bound by antibody
This increases macrophage intake
Dengue infects macrophages
Transmission of Dengue?
Human–>Mos–>Human
Treatment of Dengue?
Intensive Supportive Therapy
Prevention?
No vaccine because protection could cause the most serious forms of the disease.
What is unique about the Yellow Fever Timeline
Abrupt Onset, 48 hr remission, then toxic phase
Initial symptoms of Yellow Fever?
Initial – Fever and Chills, Severe Headache, Back Pain, Myalgia, Nausea, Vomiting
Toxic phase of Yellow Fever?
Toxic Phase – Higher Fever, Back Pain, Ab Pain, Black Vomit, nose bleeding, purpuric hemorrhages
Late stages of yellow fever?
Hypotnsion, Shock, Acidosis, Tubular Necrosis, Myocardial Dysfunction, Arrythmia, Confusion, Coma
