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Microbiology Exam #1 > Hepatitis Viruses > Flashcards

Hepatitis Viruses Flashcards

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Biology 101 flashcards
1
Q

Hepatitis A is what type of virus?

A

Picorna

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2
Q

Hepatitis B is what type of virus

A

Hepadna

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3
Q

Hepatitis C is what type of virus>

A

Flavivirdae

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4
Q

Hep A Public health claim to fame?

A

Most common vaccine-preventable disease in the world

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5
Q

Hep A genome?

A

+ssRNA with 5’viral protein
Icosahedral capsid
No Envelope

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6
Q

Hep A inactivated by…

A

Chlorine treatment
Formalin
Peracetic Acidbeta-propiolactone
UV radiation

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7
Q

Describe acute hepatitis infection.

A

Flulike Symptoms
Icteric Phase –> Dark urine, pale stool, jaundice, ab pain
Usually complete recovery

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8
Q

What is icterus?

A

Jaundice

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9
Q

Cause of jaundice?

A

Increased bilirubin levels
RBC death, heme converted to bilirubin
Bili. conjugated in liver, enters bile, and excreted

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10
Q

Long term consequences of Hep A?

A

No chronic state, No cancer

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11
Q

Serological course of Hep A

A

ALT spike, IgM anti HAV, Other anti-HAV

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12
Q

How does Hep A transfer?

A

Close personal contact
contaminated food/water
Blood Exposure

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13
Q

How is Hep A diagnosed?

A

ELISA identification of HAV-IgM Abs

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14
Q

Ig levels of acute infection?

A

IgG and IgM

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15
Q

Ig levels of very early acute?

A

IgM

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16
Q

Ig levels of person with no acute HAV infection?

A

IgG

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17
Q

Ig levels, no infection or immunity

A

None

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18
Q

Hep B genome?

A

Circular ds DNA
icosahedral
envelope

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19
Q

Proteins in Caspid?

A

Hep B Core Antigen

Soluble Core Protein

20
Q

Clinical Presentation of Acute Hep B

A

Most Asymptomatic
Jaundice hepatitis
Fulminant hepatits - GI bleeding, coming, encephalopathy, ascites

21
Q

Clinical Presentation of Chronic Hep B

A

Can be asymptomatic
Similar symptoms
May lead to serious liver damage, failure, cirrhosis, cancer

22
Q

Pathogenesis of Hep B

A

HBV infects liver
Immune mediated lysis of infected cells produce symptoms to resolve infection
Insufficient immunity leads to chronic disease

23
Q

Acute Hep B serological course?

A

HBsAg (IgG), then IgM anti-HBc, then anti-HBs

24
Q

Chronic Hep B serological course?

A

HBsAg, then IgM anti-HBc

25
Q

How is Hep B transmitted?

A

Blod, Sex, Direct Contact, Transplacental

26
Q

Treatment for Hep B?

A

Reverse Transcriptase Inhibitor (Lamivudine, Adefovir)

27
Q

Control of Hep B?

A

Scanning donated blood, Vaccination

28
Q

Infection with Hep C causes… (3)

A

Chronic Hepatitis
Cirrhosis
Hepatocellular Carcinoma

29
Q

Hep C genome?

A

+ssRNA

Enveloped

30
Q

Hep C Clinical Presentation?

A

Usually Nothing

Rarely – Jaundice, fatigue, myalgia, nausea, vomiting

31
Q

Pathogenesis of Hep C?

A

Cell-mediated immunopathology damages liver

Microscopically spotted parenchymal cells

32
Q

Sources of Hep C?

A

Injected Drug Use
Sexual
Transfusion
Mother to Child Transmission (in birth, not breastfeeding)

33
Q

Which needle stick will more likely cause disease – HCV or HIV?

A

HCV

34
Q

Treatment for Hep C?

A

Interferon
Ribavirin
Boceprevir or telaprevir (protease inhibitors)

35
Q

Hepatitis D virus’s weakness?

A

Requires Hep B to steal envelope protein

36
Q

Hep D virus type?

A

Satellite virus

Enveloped

37
Q

Only protein encoded by Hep D?

A

Delta antigen

38
Q

Hep D genome?

A

-ssRNA in covalently closed circle

39
Q

Clinical Presentation of Hep D

A

Co-infection – Severe acute disease, potential liver disease, low risk of chronic infection
Super-infection – Fulminane hepatitis, chronic HDV

40
Q

Control for Hep D?

A

Prevention of Hep B

Lamivudine

41
Q

Hep E genetics.

A

+ssRNA, icosahedral, non enveloped

42
Q

Clinical presentation of Hep E

A

Jaundice, Fatigue, Ab Pain, Loss of Appetite, Tea Urine

43
Q

How is hep E spread?

A

Fecal-Oral route, esp. in contam. water

44
Q

Parts of the world with prevalent Hep E?

A

Central/SE Asia, N and W africa, Mexico

45
Q

How to prevent Hep E?

A

Improved Sanitation

Microbiology Exam #1 (27 decks)

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