Paramyxoviridae -- Pneumovirus -- RSV Flashcards
Paramyxovirus – Explain the genetic set up
-ssRNA, Helical Caspid, Enveloped
Subfamilies within paramyxovirus family?
Paramyxovirus, Morbillivirus, Pneumovirus
Viruses replicate where?
Cytoplasm
How do paramyxos induce multinucleated cells?
Cell-Cell Fusion via F Protein
What paramyxos produce a viremia?
Measles and Mumps
Genome is associated with….
Polymerase Complex – N Protein, L Protein, and P Protein
M Protein is…
Matrix Protein associated with envelope/virion structure
Proteins seen in viral envelope? (5)
Hemagluttinin-Neuraminidase (HN) Hemagglutinin G Protein Fusion Protein M Protein
Members of Paramyxo subfamily?
Paramyxo, Rubula, Morbilli
Members of Pneumovirus subfam?
Pneumo, Metapneumo
Always brings its own….
Polymerase
Pneumovirus subgroups A and B AkA…
Respiratory Syncytial Virus
Pneumovirus is the most common cause of…
fatal acute respiratory tract infections in infants/young children
Hosts of Pneumovirus?
Humans.
Pneumovirus glycoproteins?
F and G
In children, Pneumovirus causes which type of resp. infection?
Lower respiratory tract infection
Two ways Pneumovirus presents?
Primary Bronchiolitis and Viral Pneumonia
Typically observed at what age?
2-8 months
Difference in presentation in people over 3 years?
Upper Resp. Tract
How is Pneumovirus spread?
Direct contact, Aerosols
Does Pneumovirus cause viremia?
No
Cause of developing Bronchiolitis?
Host immune response
Virus-induced necrosis of bronchiolar epithelium
Formation of mucous plugs
How does Pneumovirus spread within cells?
Cell to cell spread via F protein mediated cell fusion
Pneumovirus is the most frequent cause of….
Bronchiolitis
Treatment for Pneumovirus?
Aerosol Ribavirin
Immunoglobulin (for prophalixis)
Palivizumab (Passive Immunization)
