Paramyxoviridae -- Pneumovirus -- RSV

Question 1

Paramyxovirus – Explain the genetic set up

Answer 1

-ssRNA, Helical Caspid, Enveloped

Question 2

Subfamilies within paramyxovirus family?

Answer 2

Paramyxovirus, Morbillivirus, Pneumovirus

Question 3

Viruses replicate where?

Answer 3

Cytoplasm

Question 4

How do paramyxos induce multinucleated cells?

Answer 4

Cell-Cell Fusion via F Protein

Question 5

What paramyxos produce a viremia?

Answer 5

Measles and Mumps

Question 6

Genome is associated with….

Answer 6

Polymerase Complex – N Protein, L Protein, and P Protein

Question 7

M Protein is…

Answer 7

Matrix Protein associated with envelope/virion structure

Question 8

Proteins seen in viral envelope? (5)

Answer 8

Hemagluttinin-Neuraminidase (HN)
Hemagglutinin
G Protein
Fusion Protein
M Protein

Question 9

Members of Paramyxo subfamily?

Answer 9

Paramyxo, Rubula, Morbilli

Question 10

Members of Pneumovirus subfam?

Answer 10

Pneumo, Metapneumo

Question 11

Always brings its own….

Answer 11

Polymerase

Question 12

Pneumovirus subgroups A and B AkA…

Answer 12

Respiratory Syncytial Virus

Question 13

Pneumovirus is the most common cause of…

Answer 13

fatal acute respiratory tract infections in infants/young children

Question 14

Hosts of Pneumovirus?

Answer 14

Humans.

Question 15

Pneumovirus glycoproteins?

Answer 15

F and G

Question 16

In children, Pneumovirus causes which type of resp. infection?

Answer 16

Lower respiratory tract infection

Question 17

Two ways Pneumovirus presents?

Answer 17

Primary Bronchiolitis and Viral Pneumonia

Question 18

Typically observed at what age?

Answer 18

2-8 months

Question 19

Difference in presentation in people over 3 years?

Answer 19

Upper Resp. Tract

Question 20

How is Pneumovirus spread?

Answer 20

Direct contact, Aerosols

Question 21

Does Pneumovirus cause viremia?

Answer 21

No

Question 22

Cause of developing Bronchiolitis?

Answer 22

Host immune response
Virus-induced necrosis of bronchiolar epithelium
Formation of mucous plugs

Question 23

How does Pneumovirus spread within cells?

Answer 23

Cell to cell spread via F protein mediated cell fusion

Question 24

Pneumovirus is the most frequent cause of….

Answer 24

Bronchiolitis

Question 25

Treatment for Pneumovirus?

Answer 25

Aerosol Ribavirin
Immunoglobulin (for prophalixis)
Palivizumab (Passive Immunization)