Parvoviridae -- Human Parvovirus (B19)

Question 1

Parvovirus claim to fame?

Answer 1

Smallest virus.

Question 2

Genetic informaiton

Answer 2

ssDNA
Icosahedral
Non-enveloped

Question 3

How many serotypes?

Answer 3

One

Question 4

Most common symptom?

Answer 4

Rash in children

Question 5

Cells targeted?

Answer 5

Mitotically active, especially erythroid lineage cells of bone marrow

Question 6

Name of Erythrocyte P antigen

Answer 6

Globoside

Question 7

How does ssDNA become ds in the host?

Answer 7

Host DNA polymerases found in growing cells

Question 8

Transcriptions/Replication/Assembly occur in….

Answer 8

Nucleus

Question 9

Virus released by…

Answer 9

Cell lysis

Question 10

How does Parvo present?

Answer 10

Early – Sore throat, fever, upset stomach, headache

Late – Rash

Question 11

Bonus adult complications?

Answer 11

Joint involvement/soreness

Question 12

How is the rash in Parvovirus often described?

Answer 12

Slapped Cheek

Question 13

Parvovirus infection in pregnancy associated with…

Answer 13

Increased Fetal Loss

Question 14

What is fetal hydrops?

Answer 14

Edema of the fetus - symptoms include...
Anaemic heart failure
Pleural Effusion
Hepatosplenomegaly
Ascites

Question 15

How is fetal hydrops often diagnosed?

Answer 15

Ultrasound

Question 16

Why is Parvovirus especially dangerous for anemic people?

Answer 16

Can cause a cessation of RBC production

Causes Aplastic Crisis

Question 17

Symptoms of Aplastic Crisis?

Answer 17

Tiredness
Pale skin, lips, nails
Shortness of breath, headached, fever, fainting

Question 18

How is Parvovirus transmitted?

Answer 18

Aerosol, Transplacental

Question 19

Who typically gets parvovirus?

Answer 19

School-age and daycare kids

Question 20

Treatment?

Answer 20

None

Question 21

Prevention?

Answer 21

None