Parvoviridae -- Human Parvovirus (B19) Flashcards
Parvovirus claim to fame?
Smallest virus.
Genetic informaiton
ssDNA
Icosahedral
Non-enveloped
How many serotypes?
One
Most common symptom?
Rash in children
Cells targeted?
Mitotically active, especially erythroid lineage cells of bone marrow
Name of Erythrocyte P antigen
Globoside
How does ssDNA become ds in the host?
Host DNA polymerases found in growing cells
Transcriptions/Replication/Assembly occur in….
Nucleus
Virus released by…
Cell lysis
How does Parvo present?
Early – Sore throat, fever, upset stomach, headache
Late – Rash
Bonus adult complications?
Joint involvement/soreness
How is the rash in Parvovirus often described?
Slapped Cheek
Parvovirus infection in pregnancy associated with…
Increased Fetal Loss
What is fetal hydrops?
Edema of the fetus - symptoms include... Anaemic heart failure Pleural Effusion Hepatosplenomegaly Ascites
How is fetal hydrops often diagnosed?
Ultrasound
Why is Parvovirus especially dangerous for anemic people?
Can cause a cessation of RBC production
Causes Aplastic Crisis
Symptoms of Aplastic Crisis?
Tiredness
Pale skin, lips, nails
Shortness of breath, headached, fever, fainting
How is Parvovirus transmitted?
Aerosol, Transplacental
Who typically gets parvovirus?
School-age and daycare kids
Treatment?
None
Prevention?
None
