Togaviridae -- Rubella

Question 1

Describe the genetic set up.

Answer 1

+ssRNA genome
Icosahedral caspid
Enveloped

Question 2

Inactivators of rubella include…

Answer 2

Chemical Agents, UV, pH, Heat

Question 3

How does replication happen?

Answer 3

+RNA immediately binds to ribosomes as mRNA
2/3 genome is made a polypeptide (later cleaved into 4 protein protease and polymerase)
1/3 genome gives caspid and envelope proteins

Question 4

Other name for rubella?

Answer 4

German measles

Question 5

Why give a shit about rubella?

Answer 5

Congenital Rubella Syndrome

Question 6

How is it transmitted?

Answer 6

aerosol

Question 7

Characteristic symptom?

Answer 7

Swollen lymph glands behind ears/in neck

Rash that starts on face/neck, and moves down the body

Question 8

Bonus symptom sometimes seen in adults?

Answer 8

Arthritis

Question 9

Does rubella typically pass from mother to child?

Answer 9

In 90% of cases that the mother is infected

Question 10

Why care if the mother passes German Measles?

Answer 10

Miscarriage, Stillbirth or severe birth defects (Congenital Rubella Syndrome)

Question 11

Symptoms of Congenital Rubella Syndrome

Answer 11

Impaired Hearing (85%)
Heart Defects (50%)
Eye Defects (43%)
Autism, Thyroid Dysfunction

Question 12

Pathogenesis of Rubella?

Answer 12

Inf. nasopharynx/lungs
Spreads to Lymph Nodes and monocyte system
Viremia –> to other tissues/skin
In immunologically deficient pregnant woman, infects placenta/fetus

Question 13

Diagnosis of Rubella?

Answer 13

Rubella IgM + Rash

Question 14

Prevention of Rubella?

Answer 14

MMR