Papillomaviridae and Polyomaviridae Flashcards
Papilloma virus genetics?
ds circular DNA
Icosahedral (L1+L2)
Non-enveloped
What do the viral proteins of Papilloma virus do?
L1 – Major Caspid Protein (80%)
L2 – Minor Caspid (20%)
Where in the body does Papilloma virus replication occur?
Differentiated Skin and Mucosa Epithelium
Papilloma virus infects what species?
Only Humans
Clinical Presentation of cutaneous Papilloma virus?
Skin Warts
Viruses that cause cutaneous papilloma?
HPV-1-4
How does cutaneous papilloma develop?
Usually in childhood, adolesence
Contact at site of trauma
Recurrence is common
How does mucosal papilloma develop?
Benign Head/Neck Tumors
Anogenital Warts
Types of Benign Head and Neck Tumors?
Single Oral Papillomas and Laryngeal Papillomas
Laryngeal papillomas are associated with which viruses?
HPV-6 and HPV-11
Why are laryngeal papillomas dangerous for children?
Can obstruct the airway
Clinical Presentation of genital warts?
Squamous epithelium of external genitalia
Cauliflowerlike lesions
Papilloma viruses associated with genital warts?
HPV-6 and HPV-11
Papilloma viruses associated with cervical dysplasia?
16, 18, 31, 45
HPV is strongly associated with…
Cervical cancer
How does HPV cause cancer?
Breaking circular genome btw E1 and E2 – stops viral replication
E6 and E7 (oncogenic) are no longer regulated by E2
E6 and E7 inactivate P53 and RB
Pathogenesis of HPV?
Invades basal cell layer
Latent Phase
Viral production begins in terminally differentiated cells
Leads to morphologic atypical koilocytosis
What are koilocytes?
Multinucleated, Nuclear Enlargement, Nuclear hyperchromasia, perinuclear halo
HPV acquired through….
Direct contact, sex, birth
Control of Papilloma virus?
Podophyllin resin and Podofilox lotion – Remove Warts
Aldara cream – Immune Modifyer
Gardasil – 6, 11, 16, 18
Types of Polyomaviridae?
SV40
Murine Polyoma
BK and JC Viruses
Do BK and JC usually cause disease?
No. Only in immunocompromised.
Site of JC and BK replication?
JC – Respiratory, Urinary, and CNS
BK – Respiratory and Urinary
BK Virus Symptoms
Ureteral Stenosis (renal transplant recipients) Hemorrhagic Cystitis (Bone Marrow Transplant recip.)
Main JC Virus Symptom
Progressive Multifocal Leukoencephalopathy
What is Progressive Multifocal Leukoencephalopathy?
Infects Oligodendrocytes, Loss of White Matter
Paralysis and Death
Pathogenesis of JC and BK?
Enter respiratory, infect lymphocytes and kidney
Latent Infection of kidney (JC also B Cells+mono)
Viral Shedding in urine – UTI
Viremia and CNS infection (JC virus)
Control of BK/JC?
None
