Arbovirus -- Bunyaviridae -- Bunya+Hanta Flashcards
Unifying characteristic of arbo?
Transferred by arthropods
Most common arthropod vectors for arboviruses?
Mosquitos and Ticks
Most common arbovirus animal reservoirs?
Birds, Pigs, Monkeys, Rodents
Common symptom of arboviruses?
Fever and Rash
Maybe later encephalitis and Fever
How are arboviruses typically diagnosed?
Serology
Culture
Direct Detection Tests
Prevention of Arboviruses?
Surveilance
Control of vector
sometimes vaccination
Name the virus that is a part of the California group of Bunyaviruses.
La Cross
Describe La Cross virus
-ssRNA, Segmented
Helical Caspid
Enveloped
What do the three segments of LaCross RNA do?
L - Polymerase
M - Membrane Glycoprotein
S - Nucleocaspid Glycoprotein
Clinical Presentation of LaCross?
Encephalitis
Seizures (50% of children)
Coma (10% children)
Fever, Headache, Nausea, Vomiting, Lethargy
Most likely patients?
Children under 16
Pathogenesis of LaCross?
Insect bite Primary Viremia Infection of reticuloendothelial system and vasculoendothelial system (Mild Disease) Secondary Viremia CNS
Transmission of LaCross? Most common US location?
Triseriatus mosquito.
Midwest
La Crosse reservoir?
Chipmunks and Squirrels
Treatment?
None
Prevention?
Avoid Mosquitos
Name the two subfamilies of Bunyaviridae
Bunyavirus and hantavirus
Describe two clinical types of hantavirus presentation.
Sin Nombre Virus (Hantavirus Pulmonary Syndrome)
Asian Hantavirus – Hemorrhagic Fever+Renal Syndrome
Presentation of Hantavirus Pulmonary Syndrome?
Early Fever, Headaches, Dizziness, Chills, GI probs
Acute Respiratory Failure
Death from Circulatory Collapse
Presentation of Hemorrhagic Fever with Renal Syndrome?
Early – Sudden headaches, back/ab pain, fever, chills, blurred vision
Late – Low BP, Shock, Vasclar Leakage, Kidney Failure
Describe hantavirus pathogenesis
Infects lung parenchyma, to Lymph Nodes
Disseminates, Targets Vascular Endothelial Cells
Endo. cells damaged from virus + imm. system
Greater Cap. Permeability –> Edema
Heart Failure
Reservoir of Hanta?
Deer Mouse or Cotton Rat
How do people tend to get hanta?
Aerosolized Rodent Waste, bite, direct mucous mem contact with excretions
How do you treat hanta?
Aggressive supportive care, ventilation
Careful Monitoring or O, H2O, and BP
Prevention of Hanta?
Limited rodent contact
Precautions when cleaning out infested areas
