Arbovirus -- Bunyaviridae -- Bunya+Hanta

Question 1

Unifying characteristic of arbo?

Answer 1

Transferred by arthropods

Question 2

Most common arthropod vectors for arboviruses?

Answer 2

Mosquitos and Ticks

Question 3

Most common arbovirus animal reservoirs?

Answer 3

Birds, Pigs, Monkeys, Rodents

Question 4

Common symptom of arboviruses?

Answer 4

Fever and Rash

Maybe later encephalitis and Fever

Question 5

How are arboviruses typically diagnosed?

Answer 5

Serology
Culture
Direct Detection Tests

Question 6

Prevention of Arboviruses?

Answer 6

Surveilance
Control of vector
sometimes vaccination

Question 7

Name the virus that is a part of the California group of Bunyaviruses.

Answer 7

La Cross

Question 8

Describe La Cross virus

Answer 8

-ssRNA, Segmented
Helical Caspid
Enveloped

Question 9

What do the three segments of LaCross RNA do?

Answer 9

L - Polymerase
M - Membrane Glycoprotein
S - Nucleocaspid Glycoprotein

Question 10

Clinical Presentation of LaCross?

Answer 10

Encephalitis
Seizures (50% of children)
Coma (10% children)
Fever, Headache, Nausea, Vomiting, Lethargy

Question 11

Most likely patients?

Answer 11

Children under 16

Question 12

Pathogenesis of LaCross?

Answer 12

Insect bite
Primary Viremia
Infection of reticuloendothelial system and vasculoendothelial system (Mild Disease)
Secondary Viremia
CNS

Question 13

Transmission of LaCross? Most common US location?

Answer 13

Triseriatus mosquito.

Midwest

Question 14

La Crosse reservoir?

Answer 14

Chipmunks and Squirrels

Question 15

Treatment?

Answer 15

None

Question 16

Prevention?

Answer 16

Avoid Mosquitos

Question 17

Name the two subfamilies of Bunyaviridae

Answer 17

Bunyavirus and hantavirus

Question 18

Describe two clinical types of hantavirus presentation.

Answer 18

Sin Nombre Virus (Hantavirus Pulmonary Syndrome)

Asian Hantavirus – Hemorrhagic Fever+Renal Syndrome

Question 19

Presentation of Hantavirus Pulmonary Syndrome?

Answer 19

Early Fever, Headaches, Dizziness, Chills, GI probs
Acute Respiratory Failure
Death from Circulatory Collapse

Question 20

Presentation of Hemorrhagic Fever with Renal Syndrome?

Answer 20

Early – Sudden headaches, back/ab pain, fever, chills, blurred vision
Late – Low BP, Shock, Vasclar Leakage, Kidney Failure

Question 21

Describe hantavirus pathogenesis

Answer 21

Infects lung parenchyma, to Lymph Nodes
Disseminates, Targets Vascular Endothelial Cells
Endo. cells damaged from virus + imm. system
Greater Cap. Permeability –> Edema
Heart Failure

Question 22

Reservoir of Hanta?

Answer 22

Deer Mouse or Cotton Rat

Question 23

How do people tend to get hanta?

Answer 23

Aerosolized Rodent Waste, bite, direct mucous mem contact with excretions

Question 24

How do you treat hanta?

Answer 24

Aggressive supportive care, ventilation

Careful Monitoring or O, H2O, and BP

Question 25

Prevention of Hanta?

Answer 25

Limited rodent contact

Precautions when cleaning out infested areas