Togaviridae-Alphavirus + Reoviridae-Colorado Tick Fever Virus

Question 1

Who are the alphaviruses?

Answer 1

EEEV, WEEV, and VEEV

Question 2

Describe the genome of EEEV.

Answer 2

+ssRNA
Icosahedral Capsid
Envelope

Question 3

EEEV Clinical Presentation.

Answer 3

Fever, Headache, Ab Pain, Diarrhea

Later – CNS+Death

Question 4

Pathogenesis of EEEV.

Answer 4

Mosquito, non-neural tissue=prodromal
secondary viremia –> to CNS
Immunologically active cells chase into the brain
Immune cells cause most of the damage

Question 5

How does EEEV spread?

Answer 5

Between birds and mosquitos.

Humans and horses are dead end infections

Question 6

Reservoirs of EEEV?

Answer 6

Mosquitos, Birds (WEE+EEE)
Rodents (VEE)
Ambhibians and Reptiles

Question 7

Who gets EEEV?

Answer 7

Over 50 and Under 15
Outdoorsy
Eastern Coast

Question 8

Differences between WEEV and EEEV?

Answer 8

WEEV has a shorter incubation period (1-4 days instead of 5-10) and is more common on the West Coast

Question 9

VEEV Symptoms?

Answer 9

Mild – Asymptomatic
Moderate – Fever, Chills, Pain, Headache, Vomiting
Severe – Acute Onset High Fever, Severe Myalgia, Prostration, Confusion

Question 10

How are alphaviruses controlled?

Answer 10

Mosquito Control

Vaccines for horses and lab workers

Question 11

Genome of Reovirdae.

Answer 11

12 ds RNA segments
Icosahedral
Nonenveloped

Question 12

Describe Colorado tick fever

Answer 12

Tick Bite, Saddleback Fever, Flu-like symp., Non-specific rash
Very Rarely – Encephalitis and fatality

Question 13

Pathogenesis of Colorado Tick Fever.

Answer 13

Virus Infects Bone Marrow Cells
Blood Cell Development Arrested
Circulates through body in the blood cells

Question 14

Colorado tick fever is transmitted by

Answer 14

Wood Ricks

Question 15

Reservoir for Colorado Tick Fever is…

Answer 15

Small Mammals

Question 16

Primarily found in…

Answer 16

Western US (Esp. Colorado and Idaho)