Corona Viruses Flashcards
Whats so special about the Coronavirus genome?
Largest genome
Type of genome in a corona virus?
SS + RNA, non-segmented
Does coronavirus have an included polymerase?
No, immediately generated
Capsid type?
Helical
Describe the envelope.
Derived from intracellular membrane
Glycoproteins on the surface appear as club shaped projections
Where does corona replicate?
Cytoplasm
What does the Corona S protein bind to enter the cell?
Aminopeptidase-N and a Sialic acid-containing receptor
After polymerase is translated, what does it transcribe? (2 things)
- A Full-length, negative sense RNA template
2. Six individual mRNAs for other corona protein
How are vesicles released?
Exocytosis
Clinical manifestations of corona?
Common Cold
Common Cold Symptoms
Sore throat, Runny Nose, Congestion, Sneezing, Coughing
Do people have colds often?
2-4 Times Per Year (Adults)
6-10 times per year (Children)
Why does corona stay in upper respiratory?
Replicates best at 33-35
What do you see in cells after corona infection?
Vacuolated, Damaged Cilia, Syncytia
How does cell damage influence cold symptoms?
Triggers Inflammatory Mediators, which increase nasal secretion, local inflammation, and stimulate sneezing
What percentage of upper respiratory tract infections are caused by Corona?
10-15%
How does this bacteria survive the fecal route?
The glycoprotein corona
How is corona transmitted?
By aerosol, hand
How is corona controlled?
It isn’t.
What is SARS?
A viral respiratory illness caused by coronavirus called SARS-associated coronavirus
How is SARS spread?
Respiratory Droplets (Coughs, Sneezes)
Symptoms of SARS?
High Fever, Headache, Discomfort, Aches
Diarrhea, Pneumonia
How does SARS-CoV cause tissue damage?
Direct Lytic Effects
Multinucleated Syncytial Giant Cells
Indirect Consequences resulting from host immune response
How is corona transmitted?
Primarily via close person contact, through droplet transmission
Where did SARS come from?
Animal carriers
