Corona Viruses Flashcards
Whats so special about the Coronavirus genome?
Largest genome
Type of genome in a corona virus?
SS + RNA, non-segmented
Does coronavirus have an included polymerase?
No, immediately generated
Capsid type?
Helical
Describe the envelope.
Derived from intracellular membrane
Glycoproteins on the surface appear as club shaped projections
Where does corona replicate?
Cytoplasm
What does the Corona S protein bind to enter the cell?
Aminopeptidase-N and a Sialic acid-containing receptor
After polymerase is translated, what does it transcribe? (2 things)
- A Full-length, negative sense RNA template
2. Six individual mRNAs for other corona protein
How are vesicles released?
Exocytosis
Clinical manifestations of corona?
Common Cold
Common Cold Symptoms
Sore throat, Runny Nose, Congestion, Sneezing, Coughing
Do people have colds often?
2-4 Times Per Year (Adults)
6-10 times per year (Children)
Why does corona stay in upper respiratory?
Replicates best at 33-35
What do you see in cells after corona infection?
Vacuolated, Damaged Cilia, Syncytia
How does cell damage influence cold symptoms?
Triggers Inflammatory Mediators, which increase nasal secretion, local inflammation, and stimulate sneezing
