Vasculitis, Ischemic Dermatopathy, Panniculitis Flashcards
Breeds with familial vasculitis (all in puppies)
1) Beagles (familial necrotizing arteritis). ANCA positive.
2) GSD Familial Cutaneous Vasculopathy. Autosomal recessive. 2’ vaccination? Foot pads, nasal bridge. Self recover, but relapse with future vax.
3) Jack Russel Terrier Familial Cutaneous Vasculopathy. Vaccination? Ulcers, alopecia on boney prominences, pinnae, footpads.
4) Scottish Terrier Hereditary Vasculitis (pyogranuloma and vasculitis of the nasal planum); Autosomal dominant. Ulcer of nasal planum.
5) Shar Pei Vasculitis (life threatening! Idiopathic. Fever, hemorrhagic papules, deep ulcers, epidermal detachment. Tx GC)
Cryoglobulinemia causes
*Lead poisoning
*Upper respiratory infections
*Neoplasia (Multiple Myeloma, Lymphoma)
*Idiopathic
Systemic signs of cryoglobulinemia
*IMHA (IgM triggers it)
*Glomerulonephritis
*Thrombosis
Diagnosing cryoglobulinemia
*Immune complexes will be more severe in cold blood (refrigerator) and dissolve in warm temperature
Urticarial vasculitis causes
*Drugs
*CAFR
*Insects
*Cold
*Idiopathic
How to discern regular urticaria vs urticarial vasculitis
Vasculitic form will NOT blanch on diascopy
Normal urticaria WILL blanch on diascopy
Neonatal vasculitis pathogenesis
Foal ingesting anti-neutrophil and anti-platelet antibodies via colostrum –> forms immune complexes in their body (<4 days old) –> start bleeding.
Tx with GCs for 2 weeks. Usually a good prognosis.
Solar vasculitis skin color
Unpigmented, lightly pigmented
Often coexists with fDLE, vitiligo
Traction alopecia causes
Owners putting on cosemetic to tie the hair back (Rubber bands, Barrettes)
Traction alopecia lesions
Alopecia, thinning, scar –> well demarcated
Traction alopecia histopath
Follicular atrophy Deep arteritis (hyalinization of vessel wall)
Traction alopecia treatment
No self cure. Neglect vs pentoxifylline vs surgery
Cutaneous and Renal Glomerular Vasculopathy (AKA “alabama rot”: Breed
Racing greyhounds in USA
Many breeds in UK
Cutaneous and Renal Glomerular Vasculopathy (AKA “alabama rot”: etiology
E coli Shiga toxin (verotoxin) in raw beef
Cutaneous and Renal Glomerular Vasculopathy (AKA “alabama rot”: seasonality
Winter and summer in USA
Nov-May in the UK
Cutaneous and Renal Glomerular Vasculopathy (AKA “alabama rot”: pathogenesis
Thrombotic microangiopathy –> ischemia
Cutaneous and Renal Glomerular Vasculopathy (AKA “alabama rot”: clinical signs
Acute, with rapid deterioration
Edema, erythema –> hemorrhage, ulcers
HINDlimbs, footpads, mucosae
25% get acute kidney injury AKI. Usually AKI happens AFTER skin lesions.
Cutaneous and Renal Glomerular Vasculopathy (AKA “alabama rot”: Labwork findings
THROMBOCYTOPENIA (d/t consumption of platelets due to massive thrombosis)
AKI signs
Proteinuria, casts
Cutaneous and Renal Glomerular Vasculopathy (AKA “alabama rot”: treatment
If only skin lesions– self cure slowly, goof prognosis
Severe AKI: usually poor prognosis –> euthanize
Non-immune mediated causes of vasculitis (8)
1) Direct invasion of vascular wall (microorganisms, neoplasia)
2) Embolism (septic embolism)
3) Irradiation (UV)
4) Heat (thermal burns)
5) Water (equine immersion foot syndrome)
6) Trauma, irradiation (IV catheter)
7) Toxins
8) Hemodynamic factors (turbulence)
Immune mediated causes of vasculitis (4)
1) Immune complexes
*Antigen-antibody complexes –> complement (C3a, C5a, MAC) –> neutrophils –> granule contents, ROS released –> vasculitis
2) Anti-neutrophil cytoplasmic antibodies (ANCA)
*Ab binds to neutrophil –> activation –> granule contents, ROS released –> vasculitis
*Usual ANCA targets = neutrophil proteinase 3 & Myeloperoxidase
3) Anti-endothelial cell antibodies
4) T cells (CD8 autoreactive cells, NK cells), macrophages (ie FIP, Leishmania)
Main causes of vasculitis, general
Infection**
**Drug
*Immune-mediated dz
*CAFR
*Neoplasia
*Environmental factors (contact, heat, cold)
Proliferative (dermal) arteritis of the nasal philtrum: Breed
Saint Bernard
*Basset hound
*Bloodhound
*Dobie
*GSD
*Other large/giant breeds
Proliferative (dermal) arteritis of the nasal philtrum: Age
Mean 5 yr
Proliferative (dermal) arteritis of the nasal philtrum: Cause
Idiopathil
Familial predisposition in Saint Bernard
Proliferative (dermal) arteritis of the nasal philtrum: Clinical signs
Circular ulcer on nasal philtrum
1/3 of dogs will have PERFUSE bleeding from the lesion
Proliferative (dermal) arteritis of the nasal philtrum: Histopathology
Proliferative arteritis (deep arteries, arterioles)– Thickening of tunica media/intima: myofibroblasts that produce collagen/mucin around the arteries
Tunica interna: elastic lamina failure
Proliferative (dermal) arteritis of the nasal philtrum: Treatment
Prednisone, tacrolimus