Cat (ICADA, cutaneous mastocytosis)

Question 1

Other name for urticaria pigmentosa

Answer 1

Feline maculopapular cutaneous mastocytosis

Question 2

Breed cutaneous mastocytosis

Answer 2

*Sphynx
*Devon Rex

Question 3

Sex cutaneous mastocytosis

Answer 3

Females overrepresented

Question 4

3 clinical forms of cutaneous mastocytosis

Answer 4

1) Large papules and wheals on head, shoulders, ventral neck, axillae (polymorphic) –> spontaneous regression

2) Erythematous dermatitis with small maculopapules, crusts (monomorphic) –> poorer prognosis

3) Chronic superficial-to-deep dermatitis w/mast cells and eosinophils (pigmented) –> variable response to tx

Question 5

Treatment cutaneous mastocytosis

Answer 5

Antihistamines
Steroids
Cyclosporine

Question 6

Cutaneous mastocytosis pruritus level

Answer 6

High

Question 7

How to differentiate between MCT and cutaneous mastocytosis

Answer 7

MCT is not pruritic, cutaneous mastocytosis IS pruritic

MCT is in older cats, cutaneous mastocytosis is in younger cats

Question 8

Special stains, IHC targets to confirm mast cells

Answer 8

Giemsa stain

Tryptase IHC
KIT IHC

Question 9

Etiology cutaneous mastocytosis

Answer 9

Suspect genetic, but unknown.

Question 10

Prevention of cutaneous mastocytosis flares in humans

Answer 10

Avoid histamine triggers!
-Temp change
-Histamine rich foods
-Drugs (opiods, abx, anesthesia, NSAIDs)
-Bee stings

Question 11

Which form of cutaneous mastocytosis has spontaneous regression

Answer 11

Polycyclic form (large macules, wheals)

Question 12

Age of onset: cutaneous mastocytosis

Answer 12

~15 months old

Question 13

Breeds feline atopic syndrome

Answer 13

Abyssinian
Siamese
Persian
Devon Rex
Himalayan
Maine Coon

Question 14

Which allergy is EXCLUDED from Feline Atopic Syndrome

Answer 14

Flea allergy dermatitis

Question 15

What are Atopy Patch Tests (APT)

Answer 15

Apply allergen cutaneously

*Work via Langerhans cell-bound IgE

All FASS cats have + IDTs or prick tests, but only 1/2 have + APT

Question 16

IgG levels in FASS

Answer 16

Variable overall

Higher to rye, HDM, fleas

Question 17

IgE levels in FASS

Answer 17

SERUM TESTS ARE WORSE THAN IDST

Lower positive predictive value and sensitivity than IDST in cats

(r/o non-IgE mediated allergy. R/o MC vs serum IgE. r/o Assay validation)

Question 18

Feline asthma: protective factor

Answer 18

Early exposure to allergens is protective

Question 19

Rush ASIT in feline asthma

Answer 19

Rush ASIT works!!
SC more effective tha IN, but more AEs

Question 20

ASIT response in feline asthma

Answer 20

*Not completely allergen specific

*Response is REDUCED by concurrent systemic steroids

*Response is UNAFFECTED by inhaled steroids

Question 21

Which type of steroid does NOT affect ASIT response (inhaled vs systemic) for feline asthma

Answer 21

Inhaled

Systemic DOES reduce ASIT efficacy for feline asthma

Question 22

Histopath FAS

Answer 22

• Superficial to deep interstitial dermatitis
  -Eosinophils, MC, lymphocytes, DC, macrophages
• CD4 > CD8

Question 23

Which type of T cell predominates in FAS skin

Answer 23

CD4 T cells (>CD8)

Question 24

Which chemokines are UPREGULATED in FAS lesional skin in cats (2)

Answer 24

TARC/CCL17
RANTES/CCL5

Question 25

Which cytokines are upregulated in FASS cats?

Answer 25

Mixed Th1 and Th2

*IFN-c
*IL-2
*IL-13
*IL-18
*IL-8
*CCL5
*CCL2
*CXCL12
*SCF
*Flt3L

Question 26

Which cytokine correlates with SCORFAD (mildly) in FASS cats

Answer 26

Flt3L

Question 27

Which bacteria is most common in healthy cat skin

Answer 27

Staphylococcus epidermidis

Question 28

Which bacteria is most common in FASS skin

Answer 28

Staphylococcus felis
Staphylococcus capitis