Horse + LA Infectious dz (NAVDF Layne, Rosenkrantz) Flashcards
“Summer rash”
“Saddle sores”
“Sweating eczema”
Staphylococcal folliculitis
More common in summer; in areas that tack rubs
What can owners do to minimize risk of Staph infection
Rinse/bathe horses after being worked
Most common Staphylococcus species in horse pyodera
S. aureus
Staph species you may find in horse pyoderma
*S. aureus
*S pseudintermedius
*S hyicus hyicus
*S delphini
Staph species on healthy horse skin
CoNS
*S xylosus
*S lentus
*S epidermidiis
*S hemolyticus
*S capitis
*S sciuri
Most common MRSA lineages in horses
CC398 is increasing prevalence –> from equine hospitals!
(also common in swine)
CC8 is decreasing prevalence
T or F: humans with MRSA often have CC398 (equine hospital type)
False. Rarely causes infections in humans
T or F: Epidermic human MRSA from human hospitals has been found to cause nosocomial infections in horses (ST22, ST225)
True
Risk factors for MRSA in horses
*Hospitalization
*Preventative penicillin use
*Ceftiofur
*Aminoglycosides
*Exposure to previously colonized horses
*Antibiotics within 30 days
*Admission to neonatal ICU, hospital
Main antibiotic used for MRSA in horses
TMS, then doxycycline
Main antibiotics for MSSA in horses
Procaine penicillin, gentamicin, ceftoifur, cephalexin, chloramphenicol, rifampin
T or F: empiric enrofloxacin is a fair choice for horse pyoderma
False. Likely to induce resistance, MRSA
Most common species of Staphylococcal pyoderma in food animals
S aureus
Staphylococcus isolated from goat skin
S aureus
S hemolyticus
S warneri
S epidermidis
S chromogenes
S caprae
S hyicus
Staphylococcus isolated from cow skin
S aureus
S chromogenes
S hyicus
Staphylococcus isolated from sheep skin
S aureus
S xylosus
S epidermidis
Staphylococcus isolated from pig skin
S aureus
S hyicus
S chromogenes
S sciuri
What bacteria are considered normal commensals in most food animals
S aureus
S hyicus
Most common colonization sites of staphylococcus in food animals
Udders, tears, nasal/oral/perineal mucous membranes
Primary causes for secondary bacterial infections in food animals
*Stress from parturition/lactation
*Poor nutrition
*Overcrowding
*Transport
*Poor hygiene
*Coarse feed or bedding
*External, Internal parasitism
*Systemic illness
Which food animal more commonly develops impetigo
Dairy cows– as lesions are most common on tears/udder.
Milking equipment, lack of sanitization = predisposing factors
Predisposing factors for impetigo Staph pyoderma in dairy cows
Milking equipment, lack of sanitization
Where is impetigo staph pyoderma most common on the body of large animals
Teats/udders
Can impetigo on teats lead to mammillitis or mastitis?
Debatable
Where is folliculitis most common on farm animals
Anywhere, but sparsely haired regions are more common
-Periocular
-Muzzle
-Ventral abdomen
-Medial thighs
“Udder rot”
“Udder cleft dermatitis”
“Flexural, udder seborrhea”
“Necrotic dermatitis”
Udder dermatitis 2’ Fusobacterium, Trueperella, Treponemes»_space; Staphylococcus
NOT usually 2’ Staphylococcus, but clinically overlaps with Staph intertrigo.
Are small or large animal veterinary staff more likely to be nasal carriers of MRSA
Large animal
T or F: food animals are a reservoir of MRSA for human infection
True.
Zoonosis to hand dermatitis on dairy workers, skin wounds on pig farmers
What is the Sequence Type of MRSA that is associated with swine»_space; calves, chicken, dogs, horses, pigs, rats, humans
ST 398
Relatively non-host specific
Topical therapies for superficial, local pyoderma in food animals
*Chlorhexidine
*Povidone-iodine
Concern with systemic antibiotics in food animals
Legal issues if going into food supply
Base on C&S if you are going to do this
Other name for “Greasy pig disease”
Exudative epidermitis
Age of pigs with EE
Suckling or recently weaned pigs. Age 4 days to 6 weeks
T or F: Most cases of EE are severe
False. Usually mild. But CAN have extensive morbidity/mortality
Body regions on piglets where EE begins
Axillae, groin
Reddish/copper skin discoloration w/ thin scales
Then pustules on lips, nose, tongue, coronary band
Progresses to widespread greasy brown exudate w/oral erosions and ulcers
Clinical lesions of exudative epidermitis in piglets, advanced disease
*Widespread greasy brown exudate
*Oral erosions and ulcers
*Coronary band, heel erosions/ulcers
What sign of acantholysis will be present on abdominal skin
Positive Nikolsky sign
What non-cutaneous sign can be caused by Staphylococcus hyicus in pigs
Septic arthritis
Cause of death from exudative epidermitis in piglets
Anorexia, dehydration
Lesions are PAINFUL (not pruritic. Not pyrexic)
Exfoliative toxins that cause exudative epidermitis
*Exh A, B, C, D
*SHETA, SHETB
Target of Exh A, B, C, D & SHETA, SHETB
DSG-1
–> acantholytic kertinocytes
Digest it DSG-1. Similar to Scalded Skin Syndrome in humans
T or F: Staphylococcus hyicus is a commensal in pig skin
True.
Abrasions/trauma or co-infection with Porcine Circovirus type 2 or porcine parvovirus may predispose piglet to EE
Predisposing factors of piglets to EE
*Abrasions/trauma
*Co-infection with Porcine Circovirus type 2 or porcine parvovirus
Reportable vesicular lesions in pigs DDx
*Foot and mouth disease
*Swine vesicular disease
*Vesicular stomatitis
*Vesicular exanthema
Which antibiotics are Staphylococcus hyicus commonly resistant to
*Ceftiofur (71%)
*Penicillin G (97%)
How is exudative epidermitis best managed
Prevention: hygiene husbandry, no crowding, needle teeth
Treatment: Topical and systemic help. Use C&S
Erysipelothrix rhusiopathiae (shape, gram, O2)
Gram positive
Facultative anaerobic
Rod
Where in the body is Erysipelothrix rhusiopathiae a commensal bacteria on many mammals
Oral, tonsillar
(Outdoor, unvaccinated pigs»_space; dog, marine mammals)
3 forms of Erysipelothrix rhusiopathiae
1) Subacute = classic diamond skin disease
-Erythematous papules, wheals on throat, neck, pinnae, abdomen, thighs –> rhomboid plaques –> necrotic in center
2) Acute = fever, lameness, anorexia + purpural skin discoloration of jowls, abdomen, pinnae, legs
3) Chronic = ulceration, necrosis of pinnae, tail, feet
Clinical lesions of classic diamond skin disease
-Erythematous papules, wheals on throat, neck, pinnae, abdomen, thighs –> rhomboid plaques –> necrotic in center
Erysipelothrix rhusiopathiae
Differential for Erysipelothrix rhusiopathiae
Actinobacillus suis
What is the issue with culturing Erysipelothrix rhusiopathiae
It is slow growing– so may need PCR
Treatment for Erysipelothrix rhusiopathiae
Ampicillin, amoxicillin
FQs in small animals
T or F: Erysipelothrix rhusiopathiae is zoonotic
TRUE
Human infections are minor, self limiting. Bright red/purple swellings on hands/fingers where they touched the animal
How to prevent Erysipelothrix rhusiopathiae
Commercial vaccine available
Dermatophilus congolensis (shape, gram, O2)
Gram positive
Facultative anaerobe cocci actinomycete
TWO MORPHOLOGIES!
1) Filamentous hyphae
2) Motile zoospores
How do Dermatophilus congolensis hyphae branch
Both transverse and longitudinal separation –> packets of coccoid cells, aka Railroad tracks!
What is the infectious stage of Dermatophilus congolensis
Ovoid Zoospores!!