Genes, AISBD, Pemphigoid Antibody Targets, Hair Flashcards
Gene American Bulldog ichthyosis
NIPAL-4
(Nipa-Like Domain-Containing 4)
Co-factor for FATP4 (Fatty acid transporter 4)
Mode of inheritance American bulldog ichthyosis
Autosomal recessive
Age of onset American bulldog ichthyosis
Before weaning
Clinical signs American bulldog ichthyosis
-Generalized white scale
-Erythema + adherent scale on ventrum
-Malassezia overgrowth –> pruritus
Genes (2!) golden retriever ichthyosis
1) PNPLA-1
(Patatin-like phospholipase domain-containing protein)
Acetyltransferase
Needed for CLE formation
2) ABHD5
Mode of inheritance golden retriever ichthyosis
Autosomal recessive
Age of onset golden retriever ichthyosis
<1 year; can manifest in adults. May be transient in puppies
Clinical signs golden retriever ichthyosis
-Generalized large, white/grey scale
-Ventral hyperpigmentation
-Uncommon 2’ pyoderma, Malassezia
Mode of inheritance jack russell terrier ichthyosis
Autosomal recessive
Gene Jack Russel Terrier ichthyosis
TGM1
(Transglutaminase 1)
Formation of cornified envelope
Age of onset jack russel terrier ichthyosis
birth
Clinical signs jack russell terrier ichthyosis
-Severe generalized adherent yellow/brown scale
-2’ Malassezia overgrowth
Gene Great Dane ichthyosis
SLC27A4
(Solute Carrier Family 27 Member 4)
Encodes FATP4 synthesis of long chain fatty acids
Mode of inheritance Great Dane ichthyosis
Autosomal recessive
Age of onset Great Dane ichthyosis
Birth
Clinical signs Great Dane ichthyosis
-Greasy scale, wrinkling of face and extremities
-Nonviable into adulthood
Gene Cavalier King Charles Spaniel ichthyosis
FAM83H
(Family With Sequence Similarity 83 Member H)
Mode of inheritance CKCS ichthyosis
Autosomal recessive
Age of onset CKCS ichthyosis
Birth
Clinical signs CKCS ichthyosis
-KCS
-Scaling, abdominal pigmentation
-Curly pelage
-Pawpad hyperkeratosis
-Nail dystrophy
Gene German Shepherd Dog ichthyosis
ASPRV
(Aspartic Peptidase Retroviral)
Profilaggrin-filaggrin processing
Mode of inheritance GSD Ichthyosis
de novo
Age of onset GSD ichthyosis
birth
Clinical signs GSD ichthyosis
Generalized scaling
Gene labrador retriever pawpad hyperkeratosis, linear hyperkeratotic plaques, and follicular fronds
NSDHL
(NAD(P)H steroid dehydrogenase-like protein)
Required to convert lanosterol to cholesterol
Mode of inheritance labrador retreiver pawpad hyperkeratosis, linear hyperkeratotic plaques, and follicular fronds
X-linked semidominant
Age of onset labrador retreiver follicular parakeratosis
Puppy
Clinical signs labrador retreiver follicular parakeratosis
-Linear hyperkeratotic plaques
-Follicular fronds
-Pawpad hyperkeratosis
Gene chihuahua disorder of cornification
NSDHL
(NAD(P)H steroid
dehydrogenase-like protein)
Cholesterol processing
Mode of inheritance chihuahua Keratinocytic Nevi
X-linked semidominant
Age of onset chihuahua Keratinocytic Nevi
puppy
Clinical signs chihuahua disorder of cornification
Linear verrucous nevi
Darier disease gene
ATP2A2
Hailey Hailey disease gene
ATP2C1
Color dilution alopecia gene
MLPH
(melanophilin)
Epidermolysis bullosa simplex in Fresian cows
Keratin 5, Keratin 14
Epidermolysis bullosa simplex in Eurasier (dog)
PLEC
Plectin deficiency
Autoantibody target in paraneoplastic pemphigus
DSG3 + Plakins (ie: BPAG1, periplakin)
Epidermolysis bullosa acquisita
NC1 region of collagen 7 (COL7A1)
EBA breed
Great Dane
EBA lesion distribution
Haired skin (foot pad sloughing, frictional areas) + MC junctions + mucosae
MMP breed
GSD
MMP age, sex
middle age (6 yo), none
EBA age, sex
young, males
MMP lesion distribution
Mucocutaneous junctions, mucosae (NOT haired skin, no footpad sloughing)
MMP major autoantigen, minor autoantigen
Major: Collagen XVII
Minor: Laminin-332, BPAG1-e (BP230)
Bullous pemphigoid age, sex
middle age (5), none
Bullous pemphigoid breed
None
Bullous pemphigoid major autoantigen, minor autoantigen
Major: NC16A domain of Collagen XVII (BPAG2, BP180)
Minor: BPAG1 (BP230)
Bullous pemphigoid lesion distribution
Haired skin predominant (concave pinnae, trunk) + mucosa, MC junctions. No food pad sloughing
Junctional EBA breed
None
Junctional EBA age, sex
None, none
Junctional EBA lesion distribution
Haired skin (footpad sloughing, frictional areas) + mucosae, MC junctions. Similar to EBA!
100% have pinnae and oral cavity affected
Junctional EBA Major autoantigen
Alpha-3 and beta-3 chains of laminin-332
Mixed AISBD breed
none
Mixed AISBD age, sex
None, None
Mixed AISBD lesion distribution
haired skin predominant (concave pinnae, trunk) + mucosae, MC junctions (similar to BP). Uncommon footpad sloughing
Mixed AISBD major autoantigens
Collagen VII, Laminin 332
Linear IgA Disease breed
None
Linear IgA Disease age, sex
none, none
Linear IgA Disease lesion distribution
Mucosae, haired skin (ears, nasal planum, extremities)
Bullous SLE breed
None
Linear IgA Disease major autoantibodies
Collagen XVII
Bullous SLE age, sex
none, none
Bullous SLE lesion distribution
haired skin, footpads, mucosae, MC junctions
Bullous SLE major autoantigen
NC1 domain of Collagen VII
What AISBDs have been reported in cats?
MMP, BP
What AISBDs have been reported in pigs and horses?
Bullous pemphigoid
Which AISBD primarily affects mucous membranes?
MMP
Which AISBDs primarily affects haired skin?
BP, mixed AISBD
Which AISBDs affect both haired skin and mucosae commonly?
EBA, JEB
Pemphigus foliaceus target autoantigen in dogs
DSC1
Pemphigus vulgaris target autoantigens in dogs and horses
DSG3
DSG1 in mucocutaneous forms
Pemphigus vegetans target autoantigen
DSG1
MMP: indirect immunofluorescence w/salt split BMZ staining
Mixed
JEBA: indirect immunofluorescence w/salt split BMZ staining
Floor
(Mixed)
BP: indirect immunofluorescence w/salt split BMZ staining
Epidermal