Cutaneous Manifestations of Systemic Disease (NAVDF 2021 Outerbridge) Flashcards
Name 6 paraneoplastic skin lesions
1) Feline paraneoplastic alopecia
2) Feline thymoma-assocaited exfoliative dermatitis
3) Canine nodular dermatofibrosis
4) Canine paraneoplastic pemphigus
5) Canine superficial necrolytic dermatitis/metabolic epidermal necrosis (small % have glucagonoma trigger)
6) Canine Sertoli cells/ testicular neoplasia
What cancer is associated with feline paraneoplastic alopecia
Pancreatic adenocarcinoma +/- metastasis
Shiny skin, ventral alopecia
Clinical signs of feline paraneoplastic alopecia
Shiny skin, ventral alopecia
Hair epilates easily
Rapid onset
Dry, fissured, peeling pawpads
Increased grooming and SECONDARY Malassezia dermatitis
Often feel systemically unwell
Histopath of feline paraneoplastic alopecia
- Follicular atrophy w/ miniaturization
- Epidermal hyperplasia (opposite of what you’d see with hormonal!)
Prognosis of feline paraneoplastic aloepcia
Hair may grow back, but there is metastasis is already there. So cats will ultimately die from their cancer
Lethal acrodermatitis breed
White bull terriers
Lethal acrodermatitis mode of inheritance
Autosomal recessive
Cause of Lethal acrodermatitis
MKLN1
Defect in Zinc absorption/metabolism (?)
Lethal acrodermatitis copper and zinc levels
LOW
Lethal acrodermatitis IgA levels
LOW
How can you tell if a puppy has Lethal acrodermatitis
Stunted growth
Arched hard palate – food gets stuck in high in hard palate!
Crusted distal extremities, paws
Histopath Lethal acrodermatitis
Severe parakeratosis
Lethal acrodermatitis prognosis
Die <1 year old; fatal bronchopneumonia
Feline thymoma-associated exfoliative dermatitis: where on the body does it start
Head/neck, then generalizes
Clinical signs of Feline thymoma-associated exfoliative dermatitis
Erythema with dramati exfoliation
Histopath of Feline thymoma-associated exfoliative dermatitis
CD3+ interface dermatitis and mural folliculitis
Prognosis of Feline thymoma-associated exfoliative dermatitis
Good. If you remove the tumor, the cutaneous signs resolve.
NON-thymoma-associated exfoliative dermatitis in cats: treatment
Immunosuppressive glucocorticoids or cyclosporine
Renal Cystadenocarcinoma and Nodular Dermatofibrosis breed
GSD
Renal Cystadenocarcinoma and Nodular Dermatofibrosis Gene, mode of inheritance
FLCN, Autosomal dominant
T or F: if you note a cystadenocarcinoma on ONE kidney of a dog with Renal Cystadenocarcinoma and Nodular Dermatofibrosis, should you perform a nephrectomy
No, its likely to develop lesions on the other kidney