Tumor Suppressor Genes

Question 1

Rb

Answer 1

Associated Tumor: Retinoblastoma,osteosarcoma

Gene product: Inhibits E2F; blocks G1 -> S phase

Question 2

p53

Answer 2

Associated Tumor: Most human cancers; Li-Fraumeni syndrome

Gene product: Transcription factor for p21, blocks G1 -> S phase

Question 3

BRCA1

Answer 3

Associated Tumor: Breast and ovarian cancer

Gene product: DNA repair protein

Question 4

BRCA2

Answer 4

Associated Tumor: Breast and ovarian cancer

Gene product: DNA repair protein

Question 5

p16

Answer 5

Associated Tumor: Melanoma

Gene product:

Question 6

BRAF

Answer 6

Associated Tumor: Melanoma

Gene product: B-raf

Question 7

APC

Answer 7

Associated Tumor: Colorectal cancer (associated with FAP)

Gene product:

Question 8

WT1

Answer 8

Associated Tumor: Wilms’ Tumor (nephroblastoma)

Gene product:

Question 9

NF1

Answer 9

Associated Tumor: NeuroFibromatosis type 1

Gene product: RAS GTPase activating protein (RAS-GAP)

Question 10

NF2

Answer 10

Associated Tumor: NeuroFibromatosis type 2

Gene product: Merlin (schwannomin) protein

Question 11

DPC4

Answer 11

Associated Tumor: Pancreatic cancer

Gene product: DPC - Deleted in Pancreatic Cancer

Question 12

DCC

Answer 12

Associated Tumor: Colon cancer

Gene product: DCC - Deleted in Colon Cancer