Non-Hodgkin's lymphoma

Question 1

Burkitt’s lymphoma

Answer 1

Occurs in: Adolescents or young adults

Genetics: t(8;14)-translocation of c-myc (8) and heavy-chain Ig (14)

Comments: “Starry sky” appearance, sheet of lymphocytes with interspersed macrophates.
Associated with EBV.
Jaw lesion in endemic form in Africa; pelvis or abdomen in sproadic form.

Question 2

Diffuse large B-cell lymphoma

Answer 2

Occurs in: Usually older adults, but 20% in children

Genetics:
Comments: Most common adult NHL.
May be mature T cell in origin (20%).

Question 3

Mantle cell lymphoma

Answer 3

Occurs in: Older males

Genetics: t(11;14)-translocation of cyclin D1 (11) and heavy-chain Ig (14)

Comments: Poor prognosis; CD5+.

Question 4

Follicular lymphoma

Answer 4

Occurs in: Adults

Genetics: t(14;18)-translocation of heavy-chain Ig (14) and bcl-2 (18)

Comments: Difficult to cure; indolent course; bcl-2 inhibits apoptosis.