Nephritic Syndrome Flashcards
Acute post streptococcal glomerulonephritis
Light microscopy: glomeruli enlarged and hyper cellular, neutrophils, “lumpy-bumpy” appearance.
Electron microscopy: subepithelial immune complex (IC) humps
IF: granular appearance due to IgG, IgM and C3 deposition along GBM and mesangium
Rapidly progressive (crescentic) glomerulonephritis
LM and IF: crescent-moon shape. Crescents consist of fibrin and plasma proteins (e.g. C3b) with glomerular parietal cells, monocytes and macrophages
several disease processes may result in this pattern:
-Goodpasture’s syndrome (hematuria/hemoptysis): type II hypersensitivity; antibodies to GBM and alveolar basement membrane –> linear IF
- Wegener’s (c-ANCA)
- Microscopic polyangitis (p-ANCA)
Diffuse proliferative glomerulonephritis
Due to SLE or MPGN
Light microscopy: wire looping of capillaries
Electron microscopy: sub endothelial and sometimes intramembranous IgG-based ICs often with C3 deposition
IF- granular
Berger’s disease (IgA nephropathy)
Related to Henoch-Schonlein purport
Light microscopy: mesangial proliferation
Electron microscopy: mesangial deposits
IF: IgA-based IC deposits in mesangium
often presents/flares with a URI or acute gastroenteritis
Alport syndrome
Mutation in type IV collagen –> split basement membrane. X -linked
glomerulonephritis, deafness, less commonly eye problems