Nephritic Syndrome Flashcards

1
Q

Acute post streptococcal glomerulonephritis

A

Light microscopy: glomeruli enlarged and hyper cellular, neutrophils, “lumpy-bumpy” appearance.

Electron microscopy: subepithelial immune complex (IC) humps

IF: granular appearance due to IgG, IgM and C3 deposition along GBM and mesangium

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2
Q

Rapidly progressive (crescentic) glomerulonephritis

A

LM and IF: crescent-moon shape. Crescents consist of fibrin and plasma proteins (e.g. C3b) with glomerular parietal cells, monocytes and macrophages
several disease processes may result in this pattern:
-Goodpasture’s syndrome (hematuria/hemoptysis): type II hypersensitivity; antibodies to GBM and alveolar basement membrane –> linear IF
- Wegener’s (c-ANCA)
- Microscopic polyangitis (p-ANCA)

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3
Q

Diffuse proliferative glomerulonephritis

A

Due to SLE or MPGN

Light microscopy: wire looping of capillaries

Electron microscopy: sub endothelial and sometimes intramembranous IgG-based ICs often with C3 deposition

IF- granular

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4
Q

Berger’s disease (IgA nephropathy)

A

Related to Henoch-Schonlein purport

Light microscopy: mesangial proliferation

Electron microscopy: mesangial deposits

IF: IgA-based IC deposits in mesangium

often presents/flares with a URI or acute gastroenteritis

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5
Q

Alport syndrome

A

Mutation in type IV collagen –> split basement membrane. X -linked

glomerulonephritis, deafness, less commonly eye problems

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