Protein synthesis inhibitors

Question 1

Aminoglycosides

Answer 1

Gentamycin, Neomycin, Amikacin, Tobramycin, Streptomycin

inhibit formation of initiation complex, block translocation

severe gram negative rod infections

nephrotoxicity, neuromuscular blockade, ototoxicity, teratogen

Question 2

Tetracyclines

Answer 2

Tetracycline, doxycycline, demeclocycline, minocycline

bind to 30S and prevent attached of tRNA

Borrelia burgdorferi, M pneumoniae, Rickettsia, chlamydia

GI distress, discoloration of teeth and inhibition of bone growth in children, photosensitivity

Question 3

Macrolides

Answer 3

Azithromycin, clarithromycin, erythromycin

block translocation (50S)

mycoplasma, chlamydia, legionella, gram-positive cocci

motility issues, arrhythmia, cholestatic hepatitis, rash, eosinophilia

Question 4

Chloramphenicol

Answer 4

blocks peptidyltransferase at 50S ribosomal subunit

H influenzae, neisseria meningitidis, strep pneumo

anemia, aplastic anemia, gray baby syndrome

Question 5

Clindamycin

Answer 5

blocks peptide transfer at 50S

bacteroides fragilis, clostridium perfringens, mouth anaerobes

pseudomembranous colitis, fever, diarrhea