Chromosomal translocations Flashcards

1
Q

t(9;22) (Philadelphia chromosome)

A

CML (bcr-abl hybrid)

Philadelphia CreaML cheese.

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2
Q

t(8;14)

A

Burkitt’s lymphoma (c-myc activation)

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3
Q

t(11;14)

A

Mantle cell lymphoma (cyclin D1 activation)

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4
Q

t(14;18)

A

Follicular lymphomas (bcl-2 activation)

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5
Q

t(15;17)

A

M3 type of AML (responsive to all-trans retinoic acid)

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