Drug reactions

Question 1

coronary vasospasm

Answer 1

cocaine, sumatriptan, ergot alkaloids

Question 2

cutaneous flushing

Answer 2

vancomycin, adenosine, niacin, Ca channel blockers (VANC)

Question 3

dilated cardiomyopathy

Answer 3

doxorubicin (adriamycin), daunorubicin

Question 4

torsades de pointes

Answer 4

Class III (sotalol), and class IA (quinidine) antiarrhythmics

Question 5

agranulocytosis

Answer 5

clozapine, carbamazepine, colchicine, propylthiouracil, methimazole, dapsone

Question 6

aplastic anemia

Answer 6

chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole

Question 7

direct Coombs-positive hemolytic anemia

Answer 7

methyldopa, penicillin

Question 8

gray baby syndrome

Answer 8

chloramphenicol

Question 9

hemolysis in G6PD deficient patients

Answer 9

isoniazid (INH), sulfonamides, primaquine, aspirin, ibuprofen, nitrofurantoin (hemolysis IS PAIN)

Question 10

megaloblastic anemia

Answer 10

phenytoin, methotrexate, sulfa drugs

Question 11

thrombotic complications

Answer 11

OCPs

Question 12

Cough

Answer 12

ACE inhibitors

Question 13

Pulmonary fibrosis

Answer 13

Bleomycin, Amiodarone, busulfan

Question 14

Acute cholestatic hepatitis, jaundice

Answer 14

erythromycin

Question 15

focal to massive hepatic necrosis

Answer 15

halothane, amantita phalloides, valproic acid, acetaminophen

Question 16

hepatitis

Answer 16

INH

Question 17

pseudomembranous colitis

Answer 17

clindamycin, ampicillin

Question 18

adenocortical insufficiency

Answer 18

glucocorticoid withdrawal (HPA suppression)

Question 19

gynecomastia

Answer 19

spironolactone, digitalis, cimetidine, chronic alcohol use, estrogens, ketoconazole (Some Drugs Create Awkward Knockers)

Question 20

Hot flashes

Answer 20

Tamoxifen, clomiphene

Question 21

Hyperglycemia

Answer 21

niacin, tacrolimus, protease inhibitors, HCTZ, corticosteroids

Question 22

Hypothyroidism

Answer 22

Lithium, amiodarone, sulfonamides

Question 23

Fat redistribution

Answer 23

Glucocorticoids, protease inhibitors

Question 24

Gingival hyperplasia

Answer 24

Phenytoin, verapamil

Question 25

Gout

Answer 25

Furosemide, thiazides, niacin, cyclosporine

Question 26

Myopathies

Answer 26

Fibrates, Niacin, Colchicine, Hydroxychloroquine, Interferon-alpha, Penicillamine, Statins, Glucocorticoids

Question 27

Osteoporosis

Answer 27

corticosteroids, heparin

Question 28

Photosensitivity

Answer 28

sulfonamides, amiodarone, tetracycline

Question 29

Rash (stevens-johnson syndrome)

Answer 29

Penicillin, ethosuximide, carbamazepine, sulfa drugs, lamotrigine, allopurinol, phenytoin, phenobarbital

Question 30

SLE-like syndrome

Answer 30

Hydralazine, INH, Procainamide, Phenytoin

Question 31

Teeth (kids)

Answer 31

Tetracyclines

Question 32

Tendonitis, tendon rupture and cartilage damage

Answer 32

Fluoroquinolones

Question 33

Diabetes insipidus

Answer 33

Lithium, democlocycline

Question 34

Fanconi’s syndrome

Answer 34

Expired tetracycline

Question 35

Hemorrhagic cystitis

Answer 35

Cyclophosphamide, ifosfamide (prevent by coadministering with mesna)

Question 36

Interstitial nephritis

Answer 36

Methicillin, NSAIDs, furosemide

Question 37

SIADH

Answer 37

carbamazepine, cyclophosphamide

Question 38

Cinchonism

Answer 38

quinidine, quinine

Question 39

Parkinson-like syndrome

Answer 39

antipsychotics, reserpine, metoclopramide

Question 40

Seizures

Answer 40

Isoniazid, Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide

Question 41

Tardive dyskinesia

Answer 41

antipsychotics

Question 42

Antimuscurinic

Answer 42

Atropine, TCAs, H1-blockers, neuroleptics

Question 43

Disulfiram-like reaction

Answer 43

Metronidazole, certain cephalosporins, procarbazine, 1st-generation sulfonylureas

Question 44

Nephrotoxicity/ototoxicity

Answer 44

aminoglycosides, vancomycin, loop diuretics, cisplatin