Malignant Breast Tumors

Question 1

ductal cell carcinoma in situ (DCIS)

Answer 1

Noninvasive

Fills ductal lumen. Arises from dual hyperplasia

Early malignancy without basement membrane penetration

Question 2

comedocarcinoma

Answer 2

Noninvasive

ductal, caseous necrosis. Subtype of DCIS

Question 3

Invasive ductal

Answer 3

Invasive

Firm, fibrous, rock-hard mass with sharp margins and small, glandular, duct-like cells. Classic stellate morphology

worst and most invasive; most common (76% of all breast cancers)

Question 4

Invasive lobular

Answer 4

Invasive

Orderly row of cells (indian file)

often bilateral with multiple lesions in the same location

Question 5

Medullary

Answer 5

Invasive

Flashy, cellular, lymphocytic infiltrate

good prognosis

Question 6

Inflammatory

Answer 6

Invasive

Dermal lymphatic invasion by breast carcinoma. Peau d’orange (breast skin resembles orange peel); neoplastic cells block lymphatic drainage

50% survival at 5 years

Question 7

Paget’s disease

Answer 7

Invasive

Eczematous patches on nipple. Paget cells = large cells in epidermis with clear halo

Suggests underlying DCIS. Also seen on vulva