Malignant Breast Tumors Flashcards
ductal cell carcinoma in situ (DCIS)
Noninvasive
Fills ductal lumen. Arises from dual hyperplasia
Early malignancy without basement membrane penetration
comedocarcinoma
Noninvasive
ductal, caseous necrosis. Subtype of DCIS
Invasive ductal
Invasive
Firm, fibrous, rock-hard mass with sharp margins and small, glandular, duct-like cells. Classic stellate morphology
worst and most invasive; most common (76% of all breast cancers)
Invasive lobular
Invasive
Orderly row of cells (indian file)
often bilateral with multiple lesions in the same location
Medullary
Invasive
Flashy, cellular, lymphocytic infiltrate
good prognosis
Inflammatory
Invasive
Dermal lymphatic invasion by breast carcinoma. Peau d’orange (breast skin resembles orange peel); neoplastic cells block lymphatic drainage
50% survival at 5 years
Paget’s disease
Invasive
Eczematous patches on nipple. Paget cells = large cells in epidermis with clear halo
Suggests underlying DCIS. Also seen on vulva