Herpesviruses

Question 1

HSV-1

Answer 1

Diseases: Gingivostomatitis, keratoconjunctivitis, temporal lobe encephalitis (most common cause of sporadic encephalitis in the United States), herpes labialis A. Latent in trigeminal ganglia.
Route of transmission: Respiratory secretions, saliva

Question 2

HSV-2

Answer 2

Diseases: Herpes genitalis B, neonatal herpes. Latent in sacral ganglia.
Route of transmission: Sexual contact, perinatal

Question 3

VZV

Answer 3

Diseases: Varicella-zoster (chickenpox, shingles) C, encephalitis, pneumonia. Latent in dorsal root or trigeminal ganglia.
Route of transmission: Respiratory secretions

Question 4

EBV

Answer 4

Diseases: Infectious mononucleosis, Burkitt’s/Hodgkin’s lymphoma, nasopharyngeal carcinoma. Latent in B cells.
Route of transmission: Respiratory secretions, saliva

Question 5

CMV

Answer 5

Diseases: Congenital infection, mononucleosis (negative Monospot), pneumonia, retinitis. Infected cells have characteristic “owl’s eye” inclusions D. Latent in mononuclear cells.
Route of transmission: Congenital, transfusion, sexual contact, saliva, urine, transplant

Question 6

HHV-6

Answer 6

Diseases: Roseola: high fevers for several days that can cause seizures, followed by a diffuse macular rash.
Route of transmission: Not determined

Question 7

HHV-8

Answer 7

Diseases: Kaposi’s sarcoma (HIV patients)

Route of transmission: Sexual contact