Oncogenes

Question 1

abl

Answer 1

Associated Tumor: CML

Gene product: Tyrosine kinase

Question 2

c-myc

Answer 2

Associated Tumor: Burkitt’s lymphoma

Gene product: Transcription factor

Question 3

bcl-2

Answer 3

Associated Tumor: Follicular and undifferentiated lymphomas (inhibits apoptosis)
Gene product: Anti-apoptotic molecule

Question 4

HER2/neu (c-erbB2)

Answer 4

Associated Tumor: Breast, ovarian, and gastric carcinomas

Gene product: Tyrosine kinase

Question 5

ras

Answer 5

Associated Tumor: Colon carcinoma

Gene product: GTPase

Question 6

L-myc

Answer 6

Associated Tumor: Lung tumor

Gene product: Transcription factor

Question 7

N-myc

Answer 7

Associated Tumor: Neuroblastoma

Gene product: Transcription factor

Question 8

ret

Answer 8

Associated Tumor: Multiple endocrine neoplasia (MEN) types 2A and 2B
Gene product: Tyrosine kinase

Question 9

c-kit

Answer 9

Associated Tumor: Gastrointestinal stromal tumor (GIST)

Gene product: Cytokine receptor