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Step 1 > Antiviral therapy > Flashcards

Antiviral therapy Flashcards

1
Q

Zanamivir, oseltamivir

A

Inhibit influenza neuraminidase, decreasing release of progeny virus

treatment and prevention of influenza A and B

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2
Q

Ribavirin

A

Inhibits synthesis of guanine nucleotides by competitively inhibiting IMP dehydrogenase

RSV, chronic hep C

hemolytic anemia, severe teratogen

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3
Q

Acyclovir

A

inhibits viral DNA polymerase by chain termination

HSV, VZV

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4
Q

Ganciclovir

A

inhibits viral DNA polymerase

CMV

leukopenia, neutropenia, thrombocytopenia, renal toxicity

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5
Q

Foscarnet

A

Viral DNA polymerase inhibitor that binds to pyrophosphate-binding site of enzyme

CMV retinitis in immunocompromised patients with ganclovir fails

nephrotoxicity

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6
Q

Cidofovir

A

Preferentially inhibits viral DNA polymerase

CMV retinitis in immunocompromised patients and acyclovir resistant HSV

nephrotoxicity

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