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Pharmacology > Thyroid and Antithyroid Drugs > Flashcards

Thyroid and Antithyroid Drugs Flashcards

1
Q

Methimazole and PTU are collectively termed as?

A

Thioamides

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2
Q

How many weeks does it take for thioamides to take full effect?

A

3-4 weeks

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3
Q

Enzyme that converts iodide ion to iodine

A

Thyroid peroxidase

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4
Q

Treatment for myxedema coma

A

IV loading dose of levothyroxine (300-400mcg) followed by 50-100mcg daily

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5
Q

MOA of PTU

A

Mnemonic: TOP

Inhibits TPO,
Blocks iodine organification,
Inhibits peripheral conversion of T4 into T3

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6
Q

DOC for pregnant hyperthyroid patients

A

PTU

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7
Q

MOA of methimazole

A

Mnemonic: MOT

Blocks organification,
Inhibits TPO

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8
Q

Antithyroid drugs which cause agranulocytosis and hepatitis

A

PTU

Methimazole

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9
Q

Antithyroid drug which causes cholestatic jaundice

A

Methimazole

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10
Q

Prenatal exposure of methimazole causes what congenital disease?

A

Aplasia cutis congenita (smaller version of SJS)

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11
Q

Treatment for agranulocytosis

A

D/c drug
Administer recombinant G-CSF (Filgastrin)
Give broad-spectrum antibiotics

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12
Q

Used in the management of thyroid storm and to prepare patients for surgical resection of a hyperactive thyroid; reduces the size and vascularity of the thyroid gland; administered 10-14d before surgery

A

Iodide salts (Potassium iodide/Lugol’s solution)

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13
Q

MOA of iodide salts

A

Inhibits iodine organification and hormone release

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14
Q

Prevents radiation-induced thyroid damage

A

Iodide salts

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15
Q

Prenatal exposure of this drug causes fetal goiter

A

Iodide salts

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16
Q

Ingestion of iodine causes hypothyroidism

A

Wolf-Chaikoff effect

17
Q

Ingestion of iodine causes hyperthyroidism

A

Jod-Basedow phenomenon

18
Q

MOA of propranolol

A

A beta blocker which inhibits peripheral conversion of T4 into T3

19
Q

Used to treat thyrotoxicosis-related arrhythmias

A

Esmolol

20
Q

Antithyroid drugs which inhibit the peripheral conversion of T4 to T3

A

PTU
Propranolol
Hydrocortisone

21
Q

Drugs that cause drug-induced hyperthyroidism

A

Clofibrate
Amiodarone
Methadone

22
Q

Treatment of thyroid storm

A

Propranolol (rapid onset)

23
Q

T3 is how many times more potent than T4?

A

10x

24
Q

Antiarrhythmic drug that inhibits peripheral conversion of T4 to T3

A

Amiodarone

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