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Pharmacology > Anticancer Drugs > Flashcards

Anticancer Drugs Flashcards

1
Q

Antimetabolites

A

5-Fluorouracil
Methotrexate
Gemcitabine
6-mercaptopurine

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2
Q

Antitumor antibiotics

A

Bleomycin
Doxorubicin
Mitomycin

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3
Q

Acts on G2 phase

A

Bleomycin

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4
Q

Acts on M phase

A 
Mnemonic: MVP
M phase
Vinblastine
Vincristine
Paclitaxel
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5
Q

Cell cycle non specific

A

Alkylating agents

Antitumor antibiotics

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6
Q

Rescue therapy for cyclosphamide

A

Mesna

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7
Q

Rescue therapy for cisplatin

A

Amifostine

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8
Q

Rescue therapy for methotrexate

A

Leukovorin

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9
Q

Rescue therapy for doxorubicin

A

Dexrazoxane

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10
Q

Used for CML

A

Busulfan

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11
Q

MOA of methotrexate

A

Inhibits dihydrofolate reductase

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12
Q

Used for ALL and AML

A

6-mercaptopurine
Cytarabine
Vincristine

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13
Q

Most specific for the S phase of the cell cycle

A

Cytarabine

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14
Q

Used for pancreatic ca

A

Gemcitabine

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15
Q

Used for metastatic colorectal ca

A

Irinotecan

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16
Q

Prevents microtubule assembly (M phase)

A

Vincristine

Vinblastine

17
Q

Prevents microtubule disassembly

A

Paclitaxel

18
Q

Used for advanced breast and ovarian ca

A

Paclitaxel

19
Q

Most specific for the G2 phase

A

Bleomycin

20
Q

Used for Wilm’s tumor

A

Actinomycin D

21
Q

Used in CML and GIST

A

Imatinib

22
Q

Used for metastatic breast ca

A

Transtuzumab

23
Q

Inhibits angiogenesis (VEGF); used for DM retinopathy (proliferative)

A

Bevacizumab

24
Q

Used for hairy cell leukemia

A

Interferon-alpha

25
Q

Used for APML

A

All-trans retinoic acid

26
Q

Used for adrenal suppression

A

Prednisone

27
Q

Used for hormone-responsive breast ca (ER- and PR- positive)

A

Tamoxifen

28
Q

Alkylating agents

A

Cyclophosphamide

Cisplatin

29
Q

Used for breast cancer which express HER-2/neu receptor

A

Trastuzumab

30
Q

Causes cardiomyopathy

A

Doxorubicin

31
Q

Causes peripheral neuropathy

A

Vincristine

32
Q

Used for testicular cancer

A

PEB regimen:
Cisplatin
Etoposide
Bleomycin

33
Q

Used for Hodgkin Lymphoma

A 
MOPP regimen:
Mechlorethamine
Vincristine
Prednisone
Procarbazine
34
Q

Used for Non-Hodgkin’s lymphoma

A 
CHOP regimen:
Cyclophosphamide
Doxorubicin
Vincristine
Prednisone
\+
Rituximab
35
Q

Used for colon cancer

A

5-FU + leucovorin + oxaliplatin

36
Q

Used for ovarian cancer

A

Paclitaxel and Carboplatin

37
Q

Used for lung cancer

A

Carboplatin, paclitaxel, and bevacizumab

Pharmacology (31 decks)

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