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Antiarrhythmics Flashcards

1
Q

Class 2 acts on what phase of cardiac action potential

A

Phase 4
Beta blockers
Prolongs PR interval

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2
Q

Class 3 acts on what phase of cardiac action potential

A

Phase 3
K channel blockers
Prolongs QT interval

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3
Q

Class 4 acts on what phase of cardiac action potential

A

Phase 2
CCBs
Prolongs PR interval

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4
Q

Class 1A antiarrhythmics

Prolongs AP duration

A

Procainamide
Disopyramide
Quinidine

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5
Q

Class 1B antiarrhythmics

shortens AP duration

A

Lidocaine
Mexiletine
Tocainide
Phenytoin

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6
Q

Class 1C antiarrhythmics

A

Flecainide
Propafenone
Encainide
Moricizine

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7
Q

Class 2 antiarrhythmics

A

Propranolol

Esmolol

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8
Q

Class 3 antiarrhythmics

A

Dofetilide
Sotalol
Amiodarone

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9
Q

Class 4 antiarrhythmics

A

Verapamil

Diltiazem

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10
Q

Miscellaneous antiarrhythmics

A

Adenosine

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11
Q

Causes lupus-like syndrome

A

Procainamide

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12
Q

Has marked antimuscarinic effects

A

Disopyramide

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13
Q

Cause cinchonism (headache, vertigo, tinnitus) and ITP

A

Quinidine

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14
Q

Treatment of class 1A overdose

A

Na lactate

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15
Q

DOC for ventricular arrhythmias post-MI; used for digoxin-induced arrhythmias

A

Class 1B

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16
Q

Used in neuropathic pain

A

Mexiletine

17
Q

Causes agranulocytosis

18
Q

Drugs that cause agranulocytosis

A 
CCCAPPIT
Clozapine
Cotrimoxazole
Colchicine
Aminopyrine
Phenylbutazone
PTU
Indomethacin
Tocainide
19
Q

Used for refractory arrhythmias; contraindicated for post-MI arrhythmias

A

Flecainide

20
Q

Post-MI prophylaxis against sudden death; used for thyrotoxicosis

A

Propranolol

21
Q

Used for acute perioperative and thyrotoxic arrhythmias; used in SVT

22
Q

Treatment and prophylaxis of atrial fibrillation; causes torsades de pointes

A

Dofetilide

23
Q

Indication for sotalol

24
Q

Used for refractory arrhythmias; most efficacious of all antiarrhythmics

A

Amiodarone

25
Q

Why are dihydropyridine CCBs not useful as antiarrhythmics?

A

Evokes reflex tachycardia

26
Q

Used for SVT and migraine; causes gingival hyperplasia

27
Q

Used for SVT and raynaud’s phenomenon

28
Q

DOC for paroxysmal SVT; causes hypotension and transient chest pain

29
Q

Effective in some cases of torsades de pointes

A

Magnesium ion

30
Q

Class 1 acts on what phase of cardiac action potential

A

Phase 0
Na channel blockers
Prolongs QRS duration

Pharmacology (31 decks)

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