Histamine, serotonin, and Ergot Alkaloids; prostaglandins and eicosanoids Flashcards
2nd generation H1 blockers
Cetirizine Loratadine Fexofenadine Desloratadine Terfenadine Astemizole
SE: CYP450 inhibitor and antiandrogen effects like gynecomastia
Cimetidine
Serotonin is produced from what amino acid?
Tryptophan
Excess serotonin production is detected by?
5-hydroxy acetic acid (5-HIAA) in the urine
MOA of sumatriptan
5-HT1D/1B agonist; causes vasoconstriction
DOC for acute migraine, cluster headache
Sumatriptan
5-HT3 receptor antagonist; blocks CTZ and ENS 5-HT3 receptors
Ondansetron
Used for chemotherapy and post operative vomiting
Ondansetron
Used for irritable bowel disease
Alosetron
Prolongs QRS and QT
Dolasetron
Antidote for ergotamine overdose
Nitroprusside
Used for postpartum bleeding
Ergonovine
Methylergonovine
For leukocyte chemotaxis
LTB4
Maintains PDA
PGE1
SRS-A; causes bronchoconstriction
LTC4
LTD4
Prostaglandin E1 analog; used for PUD and for prevention of NSAID-induced gastritis; abortifacient
Misoprostol
Teratogenic effect of misoprostol
Moebius sequence
Prostaglandin E1 analog; maintains PDA; Used for erectile dysfunction
Alprostadil
Prostaglandin E2 analog; used for the induction of labor; abortifacient
Dinoprostone
Sulprostone
Prostaglandin F2 alpha analog; used to control postpartum hemorrhage
Carboprost
PGI2 analog; used for pulmonary hypertension
Epoprostenol
Prostaglandin F2 alpha analog; used in glaucoma
Latanoprost
1st generation H1 receptor antagonists
Diphenhydramine Chlorpheniramine Cyclizine Meclizine Promethazine
