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Pharmacology > Histamine, serotonin, and Ergot Alkaloids; prostaglandins and eicosanoids > Flashcards

Histamine, serotonin, and Ergot Alkaloids; prostaglandins and eicosanoids Flashcards

1
Q

2nd generation H1 blockers

A 
Cetirizine
Loratadine
Fexofenadine
Desloratadine
Terfenadine
Astemizole
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2
Q

SE: CYP450 inhibitor and antiandrogen effects like gynecomastia

A

Cimetidine

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3
Q

Serotonin is produced from what amino acid?

A

Tryptophan

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4
Q

Excess serotonin production is detected by?

A

5-hydroxy acetic acid (5-HIAA) in the urine

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5
Q

MOA of sumatriptan

A

5-HT1D/1B agonist; causes vasoconstriction

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6
Q

DOC for acute migraine, cluster headache

A

Sumatriptan

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7
Q

5-HT3 receptor antagonist; blocks CTZ and ENS 5-HT3 receptors

A

Ondansetron

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8
Q

Used for chemotherapy and post operative vomiting

A

Ondansetron

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9
Q

Used for irritable bowel disease

A

Alosetron

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10
Q

Prolongs QRS and QT

A

Dolasetron

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11
Q

Antidote for ergotamine overdose

A

Nitroprusside

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12
Q

Used for postpartum bleeding

A

Ergonovine

Methylergonovine

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13
Q

For leukocyte chemotaxis

A

LTB4

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14
Q

Maintains PDA

A

PGE1

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15
Q

SRS-A; causes bronchoconstriction

A

LTC4

LTD4

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16
Q

Prostaglandin E1 analog; used for PUD and for prevention of NSAID-induced gastritis; abortifacient

A

Misoprostol

17
Q

Teratogenic effect of misoprostol

A

Moebius sequence

18
Q

Prostaglandin E1 analog; maintains PDA; Used for erectile dysfunction

A

Alprostadil

19
Q

Prostaglandin E2 analog; used for the induction of labor; abortifacient

A

Dinoprostone

Sulprostone

20
Q

Prostaglandin F2 alpha analog; used to control postpartum hemorrhage

A

Carboprost

21
Q

PGI2 analog; used for pulmonary hypertension

A

Epoprostenol

22
Q

Prostaglandin F2 alpha analog; used in glaucoma

A

Latanoprost

23
Q

1st generation H1 receptor antagonists

A 
Diphenhydramine
Chlorpheniramine
Cyclizine
Meclizine
Promethazine

Pharmacology (31 decks)

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