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Pharmacology > Drugs Used In Coagulation Disorders > Flashcards

Drugs Used In Coagulation Disorders Flashcards

1
Q

Antiaggregants

A

PGI-2
cAMP
Adenosine

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2
Q

Causes vasoconstriction (hemostasis)

A

TXA2

Endothelin

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3
Q

Clotting factors involved in intrinsic pathway

A 
5
8
9
10
11
12
Prothrombin
Fibrinogen
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4
Q

Clotting factors involved in extrinsic pathway

A 
5
7
10
Prothrombin
Fibrinogen
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5
Q

Used for the treatment of venous thromboses

A

Heparin

Warfarin

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6
Q

Used for the treatment of arterial thromboses

A

Antiplatelets

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7
Q

MOA of aspirin

A

Nonselective, irreversible COX inhibitor

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8
Q

Prophylaxis of choice for the prevention of arterial thrombosis

A

Aspirin

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9
Q

Toxic dose of aspirin

A

150mg/kg

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10
Q

Lethal dose of aspirin

A

500mg/kg

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11
Q

Triad of aspirin hypersensitivity

A

SAMTER TRIAD
Asthma
Aspirin sensitivity
Nasal polyps

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12
Q

Expected acid-base abnormality in salicylate poisoning

A

Respiratory alkalosis with HAGMA

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13
Q

Glycoprotein IIb/IIIa inhibitors

A

Abciximab
Eptifibatide
Tirofiban

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14
Q

ADP inhibitors

A

Clopidogrel
Ticlopidine
Prasugel

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15
Q

PDE III inhibitors

A

Dipyridamole

Cilostazole

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16
Q

Anticoagulants

A

Heparin
Direct thrombin inhibitor
Warfarin

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17
Q

Function of antithrombin III

A

Inactivates thrombin and factor Xa

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18
Q

Used during PCI to prevent thrombosis

A

GP IIb/IIIa inhibitors (inhibits platelet aggregation

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19
Q

Used for the prevention of restenosis after PCI

A

ADP inhibitors (reduces platelet aggregation)

20
Q

Causes TTP

A

Ticlopidine

21
Q

Used for the prevention of thromboembolic complications of cardiac valve replacement

A

PDE III inhibitors

22
Q

Used for the management of intermittent claudication

A

Cilostazol

23
Q

Cilostazol is contraindicated in patients with?

A

Heart failure

24
Q

2 major types of anticoagulants

A

Indirect thrombin inhibitors

Direct thrombin inhibitors

25
Q

Indirect thrombin inhibitors

A

Heparin
Enoxaparin (LMWH)
Lepirudin

26
Q

Direct thrombin inhibitors

A

Coumarin derivatives (warfarin)

27
Q

Anticoagulant of choice in pregnancy

A

Heparin

28
Q

MOA of heparin

A

Activates antithrombin III

29
Q

Antidote for heparin toxicity

A

Protamine sulfate

30
Q

LMWHs

A 
Enoxaparin
Dalteparin
Tinzaparin
Danaparoid
Fondaparinux
31
Q

MOA of LMWH

A

Binds and potentiates effect of antithrombin III on factor Xa (more selective); less effect on thrombin

32
Q

Does not require aPTT monitoring

A

LMWH

33
Q

MOA of lepirudin

A

Binds to thrombin’s active site and inhibits its enzymatic action

34
Q

Anticoagulant of choice in patients with HIT

A

Lepirudin
Desirudin
Bivalirudin
Argatroban

35
Q

MOA of warfarin

A

Inhibits vitamin K epoxide reductase

36
Q

Used for chronic anticoagulation (DVT, afib, valve replacement) except in pregnancy

A

Warfarin

37
Q

Antidote for warfarin toxicity

A 
Vitamin K (slow)
FFP (fast)
38
Q

Effect of CP450 inducers on warfarin

A

Reduce anticoagulant effect

39
Q

Effect of CP450 inhibitors on warfarin

A

Increase anticoagulant effect

40
Q

Fibrinolytic drugs are used mainly for the treatment of?

A

Acute MI
Ischemic stroke
Massive pulmo embo

41
Q

tPA analogs (covert plasminogen to plasmin)

A 
Alteplase
Anistreplase
Reteplase
Streptokinase
Tenecteplase
Urokinase
42
Q

Antidote for tPA analog toxicity

A

Aminocaproic acid

43
Q

MOA of aminocaproic acid and tranexamic acid

A

Competitively inhibits plasminogen activation

44
Q

Aminocaproic acid and tranexamic acid are contraindicated in?

A

DIC

GU bleeding

45
Q

Used for hemophilia A, vWF disease, and Central DI

A

Demopressin

46
Q

Proaggregants

A

TXA2
5-HT
ADP

Pharmacology (31 decks)

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