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Pharmacology > Antifungal Agents > Flashcards

Antifungal Agents Flashcards

1
Q

MOA of ketoconazole, fluconazole, itraconazole, clotrimazole, and miconazole

A

Inhibits fungal P450-dependent enzymes blocking ergosterol synthesis (Fungistatic)

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2
Q

MOA of Echinocandins (caspofungin)

A

Inhibits B-glucan synthase decreasing fungal cell wall synthesis

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3
Q

MOA of griseofulvin

A

Interferes with microtubule formation

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4
Q

MOA of terbinafine

A

Inhibits squalene oxidase thereby interfering with ergosterol synthesis

Mnemonic: SQUATER
SQUAlene oxidase
TERbinafine

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5
Q

MOA of amphotericin B and nystatin

A

Binds to ergosterol in fungal cell membranes, forming artificial pores (fungicidal)

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6
Q

Nephrotoxic: causes RTA

A

Amphotericin B

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7
Q

Used in chronic mucocutaneous candidiasis and dermatophytosis

A

Ketoconazole

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8
Q

Used in candidiasis (esophageal, oropharyngeal, vuvovaginitis)

A

Fluconazole

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9
Q

Fluconazole is used for the treatment and prophylaxis of?

A

Cryptococcal meningitis

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10
Q

Used in sporotrichosis

A

Itraconazole

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11
Q

Used as salvage therapy for invasive aspergillosis as well as for disseminated and mucocutaneous candidiasis

A

Caspofungin

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12
Q

Causes histamine release (flushing)

A

Caspofungin

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13
Q

Potent CYP450 inducer

A

Griseofulvin

griseofulvINDUCER

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14
Q

Potent CYP450 inhibitor

A

Ketoconazole

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15
Q

Used in onychomycosis

A

Terbinafine

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16
Q

Used for candidiasis (oropharyngeal, esophageal, and vaginal)

A

Nystatin

17
Q

Used for seborrheic dermatitis and pityriasis versicolor

A

Clotrimazole

SCALPtrimazole

18
Q

MOA of flucytosine

A

Inhibits DNA and RNA polymerases

19
Q

Azoles with activity against Aspergillus

A

Itraconazole

Voriconazole

20
Q

The only azole which readily penetrates the BBB

A

Fluconazole

21
Q

Azole with the least effect on hepatic microsomal drug-metabolizing enzymes

A

Fluconazole

22
Q

Causes “shake and bake” syndrome (chills and fever caused by infusion)

A

Amphotericin B (premedication is required)

23
Q

DOC for Coccidioides immitis infection

A

Fluconazole

Pharmacology (31 decks)

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