Nucleic Acid Synthesis Inhibitors Flashcards
Weakly acidic; Have a nucleus that resembles p-aminobenzoic acid (PABA)
Sulfonamides
Short-acting sulfonamide
Sulfisoxazole
Intermediate-acting sulfonamide
Sulfamethoxazole
Long-acting sulfonamides
Sulfadoxine
Weak base; structurally similar to folic acid; reaches high concentration in prostatic and vaginal fluids
Trimethoprim
MOA of sulfonamides
Bacteriostatic inhibitor of folic acid synthesis and competitive inhibitors of dihydropteroate synthase
MOA of trimethoprim and pyrimethamine
Selective inhibitor of dihydrofolate reductase
Sulfonamide used in burn infections
Silver sulfadiazine
Mafenide acetate
Components of Co-trimoxazole
Sulfamethoxazole
Trimethoprim
Antibiotic contraindicated in G6PD
Sulfonamides
Hypersensitive spectrum of sulfonamides
EM, SJS/TEN, PAN, exfoliative dermatitis
MOA of fluoroquinolones
Inhibits DNA gyrase (topoisomerase II) in gram negatives –> blocks relaxation of supercoiled DNA
Inhibits topoisomerase IV in gram positives
1st gen fluoroquinolones
Nalidixic acid
Cinaxacin
Rosoxacin
2nd gen fluoroquinolones
Ciprofloxacin
Ofloxacin
Norfloxacin
3rd gen fluoroquinolones (respiratory quinolones)
Levofloxacin
Sparfloxacin
Grepafloxacin