Gonadal Hormones and Inhibitors

Question 1

Ethinyl estradiol increases the risk of what cancers?

Answer 1

Endometrial and breast ca

Question 2

What drug will you combine with ethinyl estradiol to prevent endometrial and breast ca?

Answer 2

Progestin

Question 3

Used for postmenopausal hormonal replacement therapy and intractable dysmenorrhea

Answer 3

Ethinyl estradiol

Question 4

Used for atrophic vaginitis

Answer 4

Diethylstilbestrol

Question 5

Causes clear cell vaginal adenocarcinoma in daughters of mother who takes this drug

Answer 5

Diethylstilbestrol

Question 6

Used in assisted reproduction and anovulation induction

Answer 6

Progestins: Norgestrel

Question 7

Causes decreased HDL and weight gain

Answer 7

Norgestrel

Question 8

Appetite stimulant

Answer 8

Megestrol

Question 9

Type of oral contraceptive which closely mimics normal menses

Answer 9

Biphasic or triphasic

Question 10

The primary action of combination hormonal contraceptives

Answer 10

Inhibition of ovulation

Question 11

Emergency contraception

Answer 11

Levonorgestrel

Question 12

Selective estrogen receptor modulator used for hormone-responsive breast ca; causes endometrial hyperplasia and endometrial ca

Answer 12

Tamoxifen

Toromifene

Question 13

SERM that is used for osteoporosis and breast cancer prevention; does not cause endometrial ca

Answer 13

Raloxifene

Question 14

SERM that is used for induction of ovulation; causes ovarian enlargement and multiple pregnancies

Answer 14

Clomiphene

Question 15

Estrogen synthesis inhibitor that is used for the management of breast cancers that are resistant to tamoxifen and for precocious puberty

Answer 15

Anastrozole (aromatase inhibitor)

Question 16

Used for endometriosis

Answer 16

Danazol (weak cytochrome P450 inhibitor and partial agonist of progestin and androgen receptors);

Medroxyprogesterone acetate by intramuscular injection

Question 17

Used for medical abortion and Cushing syndrome

Answer 17

Mifepristone

Glucocorticoid- and progesterone-receptor antagonist

Question 18

Used to treat breast cancer that is resistant to first-line antiestrogen therapy

Answer 18

Fulvestrant (estrogen receptor antagonist in all tissues)

Question 19

Androgen antagonist that is used for prostate ca

Answer 19

Flutamide

Question 20

Androgen antagonist that is used for surgical castration

Answer 20

Nilutamide

Question 21

Androgen antagonist that decreases sexual drive in men

Answer 21

Cyproterone

Question 22

5-alpha reductase inhibitor used for the treatment of BPH, male-pattern baldness, and hirsutism

Answer 22

Finasteride

Question 23

Major ovarian estrogen in women

Answer 23

Estradiol

Question 24

Example of estrogens

Answer 24

Ethinyl estradiol
Mestranol
Estrogen esters

Question 25

Example of progestins

Answer 25

Norgestrel
Medroxyprogesterone acetate
Megestrol acetate

Question 26

Example of SERMs

Answer 26

Tamoxifen
Toremifene
Raloxifene
Clomiphene

Question 27

Side effect of SERMs

Answer 27

Hot flushes
Thromboembolism
Endometrial hyperplasia

Question 28

SERM used for osteoporosis

Answer 28

Raloxifene

Question 29

SERM used for ovulation induction

Answer 29

Clomiphene

Question 30

GnRH agonist

Answer 30

Leuprolide

Question 31

GnRH receptor antagonist

Answer 31

Ganirelix

Cetrorelix

Question 32

Used in combination with misoprostol for medical abortion

Answer 32

Mifepristone (progestin and glucocorticoid receptor antagonist)

Question 33

An antifungal drug which inhibits gonadal and adrenal steroid synthesis; used to suppress adrenal steroid synthesis in patients with steroid-responsive metastatic prostate cancer

Answer 33

Ketoconazole

Question 34

Men who use large doses of anabolic steroids are at increased risk of?

Answer 34

Cholestatic jaundice and elevation of aspartate transaminase levels in the blood