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Pharmacology > Bacterial Cell Wall Synthesis Inhibitors > Flashcards

Bacterial Cell Wall Synthesis Inhibitors Flashcards

1
Q

MOA of beta-lactam antibiotics

A

Binds to PBPs inhibiting transpeptidation reaction

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2
Q

Beta-lactamase inhibitors

A

Clavulanic acid
Sulbactam
Tazobactam

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3
Q

Renal tubular reabsorption of penicillin is inhibited by?

A

Probenecid

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4
Q

A very narrow spectrum beta lactam which causes interstitial nephritis

A

Methicillin

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5
Q

A very narrow spectrum beta lactam which causes neutropenia

A

Nafcillin

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6
Q

Very narrow spectrum beta lactams

A

Methicillin
Nafcillin
Oxacillin
Cloxacillin

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7
Q

Antimicrobial coverage of very narrow spectrum beta lactams

A

Staphylococcal infections; they are resistant to inactivation by beta-lactamase (penicillinase)

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8
Q

Narrow spectrum beta lactams

A

Penicillin G

Penicillin V

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9
Q

Antimicrobial coverage of narrow spectrum beta lactams

A

Streptococcal
Pneumococcal
Meningococcal
Syphilis

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10
Q

Extended spectrum beta lactams

A

Ampicillin

Amoxicillin

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11
Q

Antimicrobial coverage of extended spectrum beta lactams

A 
Listeria
E. coli
Proteus
H. influenzae
Moraxella
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12
Q

Causes pseudomembranous colitis and rash

A

Ampicillin

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13
Q

Extended spectrum beta lactams have synergistic effect with?

A

Aminoglycosides

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14
Q

Antipseudomonal penicillins

A

Take Care of Pseudomonas
Ticarcillin
Carbenicillin
Piperacillin

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15
Q

Antimicrobial coverage of Antipseudomonal penicillins

A

Pseudomonas
Enterobacter
Klebsiella

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16
Q

1st generation cephalosporins

A 
FADer, help me FAZ my PHarmacology boards
Cefadroxil
Cefazolin
Cephalotin
Cephapirin
Cephradine
Cephalexin
17
Q

Used for surgical prophylaxis

A

1st gen cephalosporin

18
Q

Increases the toxicity of aminoglycosides

A

Cephalosporins

19
Q

Antimicrobial coverage of 1st gen cephalosporins

A

PEcKs 1st
Proteus
E. coli
Klebsiella

20
Q

Antimicrobial coverage of 2nd gen cephalosporins

A 
1st gen plus
Haemophilus
Enterobacter
Neisseria
Serratia
21
Q

Causes disulfiram reaction

A

Cefamandole
Cefotetan
Cefoperazone

22
Q

3rd gen cephalosporins

A 
Cefetamet
Cefpodoxin
Cefoperazone
Cefotaxime
Cefixime
Ceftriaxone
Ceftazidime
Ceftizoxime
Ceftibuten
23
Q

Antipseudomonal penicillins

A

Ceftazidime
Cefepime
Cefoperazone

24
Q

Miscellaneous beta lactams

A

Imipenem-cilastatin
Ertapenem
Meropenem

25
Q

Inhibits renal metabolism of imipenem

A

Cilastatin

26
Q

MOA of vancomycin

A

Inhibits cell wall synthesis by binding to D-Ala-D-Ala terminus of nascent peptidoglycan

27
Q

Indications for vancomycin

A

MRSA

Pseudomembranous colitis

28
Q

Causes red man syndrome, neprotoxicity, and ototoxicity

A

Vancomycin

29
Q

Antibiotics of last resort

A 
I AM your Last Shot at Victory
Imipenem
Amikacin
Meropenem
Linezolid
Streptogramins
Vancomycin
30
Q

Indication of cycloserine

A

Drug-resistant TB (2nd line drug)

31
Q

Bactericidal antibiotics

A 
Very Finely Proficient At Murder
Vancomycin
Fluoroquinolones
Penicillins
Aminoglycosides
Metronidazole

Pharmacology (31 decks)

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