Bacterial Cell Wall Synthesis Inhibitors Flashcards
MOA of beta-lactam antibiotics
Binds to PBPs inhibiting transpeptidation reaction
Beta-lactamase inhibitors
Clavulanic acid
Sulbactam
Tazobactam
Renal tubular reabsorption of penicillin is inhibited by?
Probenecid
A very narrow spectrum beta lactam which causes interstitial nephritis
Methicillin
A very narrow spectrum beta lactam which causes neutropenia
Nafcillin
Very narrow spectrum beta lactams
Methicillin
Nafcillin
Oxacillin
Cloxacillin
Antimicrobial coverage of very narrow spectrum beta lactams
Staphylococcal infections; they are resistant to inactivation by beta-lactamase (penicillinase)
Narrow spectrum beta lactams
Penicillin G
Penicillin V
Antimicrobial coverage of narrow spectrum beta lactams
Streptococcal
Pneumococcal
Meningococcal
Syphilis
Extended spectrum beta lactams
Ampicillin
Amoxicillin
Antimicrobial coverage of extended spectrum beta lactams
Listeria E. coli Proteus H. influenzae Moraxella
Causes pseudomembranous colitis and rash
Ampicillin
Extended spectrum beta lactams have synergistic effect with?
Aminoglycosides
Antipseudomonal penicillins
Take Care of Pseudomonas
Ticarcillin
Carbenicillin
Piperacillin
Antimicrobial coverage of Antipseudomonal penicillins
Pseudomonas
Enterobacter
Klebsiella
1st generation cephalosporins
FADer, help me FAZ my PHarmacology boards Cefadroxil Cefazolin Cephalotin Cephapirin Cephradine Cephalexin
Used for surgical prophylaxis
1st gen cephalosporin
Increases the toxicity of aminoglycosides
Cephalosporins
Antimicrobial coverage of 1st gen cephalosporins
PEcKs 1st
Proteus
E. coli
Klebsiella
Antimicrobial coverage of 2nd gen cephalosporins
1st gen plus Haemophilus Enterobacter Neisseria Serratia
Causes disulfiram reaction
Cefamandole
Cefotetan
Cefoperazone
3rd gen cephalosporins
Cefetamet Cefpodoxin Cefoperazone Cefotaxime Cefixime Ceftriaxone Ceftazidime Ceftizoxime Ceftibuten
Antipseudomonal penicillins
Ceftazidime
Cefepime
Cefoperazone
Miscellaneous beta lactams
Imipenem-cilastatin
Ertapenem
Meropenem
Inhibits renal metabolism of imipenem
Cilastatin
MOA of vancomycin
Inhibits cell wall synthesis by binding to D-Ala-D-Ala terminus of nascent peptidoglycan
Indications for vancomycin
MRSA
Pseudomembranous colitis
Causes red man syndrome, neprotoxicity, and ototoxicity
Vancomycin
Antibiotics of last resort
I AM your Last Shot at Victory Imipenem Amikacin Meropenem Linezolid Streptogramins Vancomycin
Indication of cycloserine
Drug-resistant TB (2nd line drug)
Bactericidal antibiotics
Very Finely Proficient At Murder Vancomycin Fluoroquinolones Penicillins Aminoglycosides Metronidazole
