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Pharmacology > Hypothalamic and Pituitary Hormones > Flashcards

Hypothalamic and Pituitary Hormones Flashcards

1
Q

Anterior pituitary hormones which act through G protein-coupled receptors

A

TSH
ACTH
FSH
LH

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2
Q

Anterior pituitary hormones which act through JAK/STAT receptors

A

GH

Prolactin

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3
Q

Effect of endogenous GnRH on LH and FSH

A

Stimulates release

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4
Q

Effect of exogenous GnRH on LH and FSH

A

Inhibits release

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5
Q

MOA of Somatropin (Growth hormone)

A

Increases release of IGF-1 in the liver and cartilage

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6
Q

MOA of octreotide (somatostatin analog)

A

Suppresses secretion of growth hormone, IGF-1, and serotonin and GI peptides

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7
Q

Used in patients with GH deficiency, genetic diseases associated with short stature (Turner, Noonan, Prader-Willi), failure to thrive, and AIDS wasting

A

Somatropin

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8
Q

Used in patients with acromegaly, pituitary adenoma (GH-secreting), carcinoid, gastrinoma, glucagonoma, and variceal bleeding

A

Octreotide

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9
Q

Inhibits the release of GH, glucagon, insulin, and gastrin

A

Somatostatin

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10
Q

GH receptor antagonist that is approved for treatment of acromegaly

A

Pegvisomant

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11
Q

Directs follicle development in women

A

FSH

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12
Q

Collaborates in regulating ovarian steroidogenesis

A

FSH and LH

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13
Q

Regulates spermatogenesis

A

FSH

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14
Q

Stimulates androgen production in men

A

LH

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15
Q

Final stage of oocyte maturation is induced with an injection of?

A

LH or hCG

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16
Q

An FSH analog (FSH receptor agonist) used for controlled ovarian stimulation and for men who are infertile due to hypogonadism

A

Follitropin alfa

17
Q

An LH analog which is used for hypogonadotropic hypogonadism

A

Choriogonadotropin alfa

18
Q

A GnRH analog (LH receptor agonist) used for endometriosis, myoma uteri, precocious puberty, and prostate ca

A

Leuprolide

19
Q

Drug that prevents acute flare ups of prostate ca caused by Leuprolide

A

Flutamide

20
Q

A GnRH antagonist which prevents premature LH surge

A

Ganirelix

21
Q

Does not cause flare ups of prostate ca

A

Ganirelix

22
Q

A partial agonist at D2 receptors in the brain which is used for the treatment of hyperprolactinemia

A

Bromocriptine

23
Q

A vasopressin V2 receptor agonist which is used for the treatment of central diabetes insipidus, hemophilia A, and von Willebrand’s disease

A

Desmopressin

24
Q

Syndrome of polyuria, polydipsia, and hypernatremia

A

Diabetes insipidus

25
Q

Antagonist of V1a and V2 receptors which is used for SIADH and hyponatremia

A

Conivaptan

26
Q

A vasopressin receptor antagonist which is more selective for vasopressin V2 receptors

A

Tolvaptan

27
Q

An oxytocin receptor antagonist which is used for tocolysis of preterm labor

A

Atosiban

28
Q

Hormones derived from basophilic cells

A 
B FLAT
FSH
LH
ACTH
TSH

Pharmacology (31 decks)

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