Hypothalamic and Pituitary Hormones Flashcards
Anterior pituitary hormones which act through G protein-coupled receptors
TSH
ACTH
FSH
LH
Anterior pituitary hormones which act through JAK/STAT receptors
GH
Prolactin
Effect of endogenous GnRH on LH and FSH
Stimulates release
Effect of exogenous GnRH on LH and FSH
Inhibits release
MOA of Somatropin (Growth hormone)
Increases release of IGF-1 in the liver and cartilage
MOA of octreotide (somatostatin analog)
Suppresses secretion of growth hormone, IGF-1, and serotonin and GI peptides
Used in patients with GH deficiency, genetic diseases associated with short stature (Turner, Noonan, Prader-Willi), failure to thrive, and AIDS wasting
Somatropin
Used in patients with acromegaly, pituitary adenoma (GH-secreting), carcinoid, gastrinoma, glucagonoma, and variceal bleeding
Octreotide
Inhibits the release of GH, glucagon, insulin, and gastrin
Somatostatin
GH receptor antagonist that is approved for treatment of acromegaly
Pegvisomant
Directs follicle development in women
FSH
Collaborates in regulating ovarian steroidogenesis
FSH and LH
Regulates spermatogenesis
FSH
Stimulates androgen production in men
LH
Final stage of oocyte maturation is induced with an injection of?
LH or hCG
An FSH analog (FSH receptor agonist) used for controlled ovarian stimulation and for men who are infertile due to hypogonadism
Follitropin alfa
An LH analog which is used for hypogonadotropic hypogonadism
Choriogonadotropin alfa
A GnRH analog (LH receptor agonist) used for endometriosis, myoma uteri, precocious puberty, and prostate ca
Leuprolide
Drug that prevents acute flare ups of prostate ca caused by Leuprolide
Flutamide
A GnRH antagonist which prevents premature LH surge
Ganirelix
Does not cause flare ups of prostate ca
Ganirelix
A partial agonist at D2 receptors in the brain which is used for the treatment of hyperprolactinemia
Bromocriptine
A vasopressin V2 receptor agonist which is used for the treatment of central diabetes insipidus, hemophilia A, and von Willebrand’s disease
Desmopressin
Syndrome of polyuria, polydipsia, and hypernatremia
Diabetes insipidus
Antagonist of V1a and V2 receptors which is used for SIADH and hyponatremia
Conivaptan
A vasopressin receptor antagonist which is more selective for vasopressin V2 receptors
Tolvaptan
An oxytocin receptor antagonist which is used for tocolysis of preterm labor
Atosiban
Hormones derived from basophilic cells
B FLAT FSH LH ACTH TSH
