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Pharmacology > Drugs Used In TB > Flashcards

Drugs Used In TB Flashcards

1
Q

MOA of ethambutol

A

Inhibits arabinosyl transferases involved in the synthesis of arabinogalactan in mycobacterial cell wall

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2
Q

MOA of pyrazinamide

A

Unknown

Converted to pyrazinoic acid under acidic conditions of macrophage lysosomes

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3
Q

MOA of streptomycin

A

Inhibits protein synthesis by binding to 30s subunit;

Binds to S12 ribosomal subunit inhibiting protein synthesis

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4
Q

Hepatotoxic anti-TB drugs

A

ISO a Red PYRe

Isoniazid

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5
Q

Contraindicated in G6PD
Causes drug-induced lupus
Neurotoxic

A

Isoniazid

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6
Q

Most important drug used in TB

A

Isoniazid

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7
Q

Potent CYP450 inhibitor

A

Isoniazid

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8
Q

Causes red-orange urine

A

Rifampicin

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9
Q

Causes red-green color blindness, retrobulbar neuritis, and color blindness

A

Ethambutol

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10
Q

Causes hyperuricemia

A

Ethambutol

Pyrazinamide

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11
Q

Causes nongouty polyarthralgia and porphyria

A

Pyrazinamide

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12
Q

Also known as sterilizing agent

A

Pyrazinamide

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13
Q

Treatment for category I

A

2 HRZE

4 HR

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14
Q

Treatment for category II

A

2 HRZES and 1 HRZE

5 HR

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15
Q

Category III

A

2 HRZ

4 HR

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16
Q

What is MDRTB?

A

Resistance to at least isoniazid and rifampicin

17
Q

What is XDRTB?

A

Resistance to isoniazid, rifampin, plus any fluroquinolone and atleast one of three injectable second-line drugs (i.e., amikacin, kanamycin, or capreomycin)

18
Q

MOA of isoniazid

A

Inhibits mycolic acid synthesis

19
Q

Potent CYP450 inducer

A

Rifampicin

20
Q

MOA of rifampicin

A

Inhibits DNA-dependent RNA polymerase

20
Q

Isoniazid inhibits the metabolism of what drugs?

A

Warfarin
Carbamazepine
Phenytoin

21
Q

Causes hemolysis in G6PD deficiency

A

Isoniazid

22
Q

Bacteriostatic anti-TB drugs

A

Ethambutol

Pyrazinamide

23
Q

The active form of pyrazinamide is?

A

Pyrazoic acid

24
Q

Requires bioactivation

A

Isoniazid

Pyrazinamide

25
Q

Causes porphyria

A

Pyrazinamide

26
Q

Causes hyperuricemia

A

Pyrazinamide

Ethambutol

27
Q

Causes cholestasis

A

Rifampicin

28
Q

Avoided in pregnancy

A

Pyrazinamide

30
Q

Mechanism of resistance to ethambutol

A

Mutations in the emb gene

31
Q

Causes flu-like syndrome with intermittent dosing

A

Rifampicin

Pharmacology (31 decks)

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