Drugs Used In TB Flashcards
MOA of ethambutol
Inhibits arabinosyl transferases involved in the synthesis of arabinogalactan in mycobacterial cell wall
MOA of pyrazinamide
Unknown
Converted to pyrazinoic acid under acidic conditions of macrophage lysosomes
MOA of streptomycin
Inhibits protein synthesis by binding to 30s subunit;
Binds to S12 ribosomal subunit inhibiting protein synthesis
Hepatotoxic anti-TB drugs
ISO a Red PYRe
Isoniazid
Contraindicated in G6PD
Causes drug-induced lupus
Neurotoxic
Isoniazid
Most important drug used in TB
Isoniazid
Potent CYP450 inhibitor
Isoniazid
Causes red-orange urine
Rifampicin
Causes red-green color blindness, retrobulbar neuritis, and color blindness
Ethambutol
Causes hyperuricemia
Ethambutol
Pyrazinamide
Causes nongouty polyarthralgia and porphyria
Pyrazinamide
Also known as sterilizing agent
Pyrazinamide
Treatment for category I
2 HRZE
4 HR
Treatment for category II
2 HRZES and 1 HRZE
5 HR
Category III
2 HRZ
4 HR
What is MDRTB?
Resistance to at least isoniazid and rifampicin
What is XDRTB?
Resistance to isoniazid, rifampin, plus any fluroquinolone and atleast one of three injectable second-line drugs (i.e., amikacin, kanamycin, or capreomycin)
MOA of isoniazid
Inhibits mycolic acid synthesis
Potent CYP450 inducer
Rifampicin
MOA of rifampicin
Inhibits DNA-dependent RNA polymerase
Isoniazid inhibits the metabolism of what drugs?
Warfarin
Carbamazepine
Phenytoin
Causes hemolysis in G6PD deficiency
Isoniazid
Bacteriostatic anti-TB drugs
Ethambutol
Pyrazinamide
The active form of pyrazinamide is?
Pyrazoic acid
Requires bioactivation
Isoniazid
Pyrazinamide
Causes porphyria
Pyrazinamide
Causes hyperuricemia
Pyrazinamide
Ethambutol
Causes cholestasis
Rifampicin
Avoided in pregnancy
Pyrazinamide
Mechanism of resistance to ethambutol
Mutations in the emb gene
Causes flu-like syndrome with intermittent dosing
Rifampicin
