Drugs For Hyperlipidemias

Question 1

Hepatotoxicity is increased when ezetimibe is used with?

Answer 1

Statins

Question 2

Avoided in patients with hypertriglyceridemia because it raises TG and VLDL levels

Answer 2

Alcohol

Question 3

HMG-Coa Synthase is used for?

Answer 3

Ketogenesis

Question 4

HMG-Coa reductase is used for?

Answer 4

Cholesterol synthesis

Question 5

Bile acid-binding resins (BARs)

Answer 5

Cholestyramine
Colesevelam
Colestipol

Mnemonic: ChoCoCo BAR

Question 6

Used for the management of pruritus in cholestasis and digitalis toxicity

Answer 6

Bile acid binding-resins (BARs)

Question 7

SE of bile acid-binding resins

Answer 7

Constipation
Bloating
Gritty taste
Steatorrhea
Gallstones (rare)
Malabsorption of fat soluble vitamins

Question 8

Increases TGs and VLDL in patients with high TGs

Answer 8

BARs

Question 9

BARs should be avoided in patients with?

Answer 9

Diverticulitis

Question 10

MOA of ezetimibe

Answer 10

Selective inhibitor of the NPC1L1 transporter, decreasing intestinal absorption of cholesterol and other phytosterols

Question 11

Ezetimibe have synergistic LDL-lowering effects with?

Answer 11

Statins

Question 12

Cholesterol analog; decreases intestinal absorption of cholesterol and other phytosterols

Answer 12

Sitosterol

Question 13

Most effective agent for increasing HDL levels; decreases VLDL and LDL

Answer 13

Niacin (nicotinic acid)

Question 14

Niacin is contraindicated in patients with?

Answer 14

DM
Gout
PUD

Question 15

Flushing caused by niacin is reduced by giving?

Answer 15

Aspirin

Question 16

Drugs that cause flushing

Answer 16

VANC
Vancomycin
Adenosine
Niacin
CCBs

Question 17

MOA of fibrates

Answer 17

Activates PPAR-alpha; increases synthesis of lipoprotein lipase and apolipoproteins (apoA-I and apoA-II); increases HDL

Mnemonic: FALL-TRI
Fibrates
Alpha (PPAR-alpha)
Lipoprotein 
Lipase increases
TRIglycerides lowers

Question 18

DOC for hypertriglyceridemia

Answer 18

Fibrates

Question 19

Fibrates

Answer 19

Gemfibrozil
Fenofibrate
Bezafibrate

Mnemonic: FIB in the middle

Question 20

Used in fat redistribution syndrome

Answer 20

Fibrates

Question 21

Causes cholesterol gallstones

Answer 21

Fibrates

Question 22

Used for familial hypercholesterolemia

Answer 22

Niacin + statin or

Statin + ezetimibe

Question 23

Used for familial combined hypercholesterolemia

Answer 23

Niacin + resin or

Statin + fibrate

Question 24

Increased risk of cholelithiasis

Answer 24

Fibrate + resin

Question 25

Impaired statin absorption

Answer 25

Statin + resin

Question 26

There is increased risk of myopathy and rhabdomyolysis when statins are used with?

Answer 26

Fibrates

Question 27

MOA of niacin

Answer 27

Niacin inhibits VLDL secretion, in turn decreasing production of LDL. Increased clearance of VLDL via the LPL pathway contributes to reduction of triglycerides

Question 28

Contraindicated in pregnancy

Answer 28

Statins

Question 29

Causes hyperuricemia and glucose intolerance

Answer 29

Niacin