Corticosteroids and Antagonists

Question 1

Intermediate-acting glucocorticoids

Answer 1

Triamcinolone
Paramethasone
Fluprednisolone

Question 2

Highest anti inflammatory effect

Answer 2

Betamethasone

Question 3

Used for acute adrenal insufficiency, insect bites, contact dermatitis, status asthmaticus, and thyroid storm

Answer 3

Hydrocortisone

Question 4

Used for autoimmune and neoplastic diseases as well as for prevention of organ transplant rejection

Answer 4

Prednisone

Question 5

Hastens fetal lung maturation

Answer 5

Betamethasone

Dexamethasone

Question 6

Glucocorticoid with the highest topical activity

Answer 6

Dexamethasone

Question 7

Glucocorticoid with the longest duration of action

Answer 7

Dexamethasone (24-36hrs)

Question 8

Highest salt-retaining property

Answer 8

Fludrocortisone

Question 9

Used for chronic adrenal insufficiency (Addison’s disease), CAH, and as an adrenal replacement therapy post-adrenalectomy

Answer 9

Fludrocortisone (mineralocorticoid)

Question 10

Drugs which inhibit adrenal steroid synthesis

Answer 10

Ketoconazole
Aminoglutethimide
Metyrapone

Question 11

Inhibits desmolase, blocking conversion of cholesterol to pregnenolone which leads to reduced synthesis of all hormonally active steroids

Answer 11

Aminoglutethimide

Corticosteroid antagonist

Question 12

Drugs used for the treatment of Cushing’s syndrome

Answer 12

Aminoglutethimide
Ketoconazole
Metyrapone

Question 13

DOC for pregnant patients with Cushing’s syndrome

Answer 13

Metyrapone

Question 14

MOA of metyrapone

Answer 14

Inhibits 11B-hydroxylase, interfering with cortisol and corticosterone (aldosterone) synthesis

Question 15

In the normal adult, in the absence of stress, how much cortisol is secreted daily?

Answer 15

10-20mg

Question 16

Conditions where corticosteroid-binding globulin is increased

Answer 16

Pregnancy
Estrogen administration
Hyperthyroidism

Question 17

Peak of ACTH secretion occurs when?

Answer 17

Early morning hours and after meals

Question 18

Dexamethasone suppression test result:
Low ACTH
High cortisol

Answer 18

Cortisol-producing adrenal tumor

Question 19

Dexamethasone suppression test result:
High ACTH
High cortisol

Answer 19

Ectopic ACTH-producing tumor

Question 20

Dexamethasone suppression test result:
Low ACTH
Low cortisol

Answer 20

Normal

Question 21

Dexamethasone suppression test result:

Morning cortisol concentration: >5mcg/dL

Answer 21

Cushing’s syndrome

Question 22

Used for the treatment of primary aldosteronism

Answer 22

Spironolactone

Question 23

Used in the treatment of hirsutism in women

Answer 23

Spironolactone

Question 24

Long-acting glucocorticoids

Answer 24

Betamethasone

Dexamethasone