Antihelmithic Drugs Flashcards
DOC for E. granulosus
Albendazole
DOC for ascariasis, ancylostoma, necator, and capillariasis
Albendazole
DOC for trichuris
Mebendazole
DOC for enterobius
Pyrantel pamoate
DOC for strongyloides
Ivermectin
DOC for wuchereria and brugia
DEC
DOC for trichinella
Thiabendazole
DOC for hydatid disease
Albendazole
Drug of choice for filariasis and eye worm disease
DEC
May cause Mazzotti reaction
DEC
Ivermectin
DOC for roundworm and hookworm infections
Pyrantel pamoate
Praziquantel is contraindicated in?
Ocular Cysticercosis
Contraindicated in pregnancy
Mebendazole
Ivermectin
Thiabendazole
DOC for all cestodes except E. granulosus
Praziquantel
MOA of praziquantel
Increases membrane permeability to calcium, causing marked contraction initially and then paralysis of trematode and cestode muscles; this is followed by vacuolization and parasite death
MOA of pyrantel pamoate
Stimulates nicotinic receptors present at neuromuscular junctions of nematodes
MOA of mebendazole
Selectively inhibits microtubule synthesis and glucose uptake in nematodes
MOA of ivermectin
Intensifies GABA-mediated neurotransmission in nematodes and causes immobilization of parasites
MOA of DEC
Immobilizes microfilariae
MOA of albendazole
Inhibits microtubule assembly
