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Pharmacology > Antiviral Chemotherapy and Prophylaxis > Flashcards

Antiviral Chemotherapy and Prophylaxis Flashcards

1
Q

MOA of Foscarnet

A

Inhibits viral RNA polymerase, DNA polymerase, and HIV reverse transcriptase

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2
Q

Antiviral spectrum of acyclovir

A

HSV-1
HSV-2
VZV

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3
Q

Antiviral spectrum of ganciclovir

A

CMV
HSV-1
HSV-2
VZV

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4
Q

Inhibits fusion between the HSV envelope and plasma membranes

A

Docosanol

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5
Q

Used in CMV retinitis, acyclovir-resistance, ganciclovir-resistance, genital warts, molluscum contagiosum, and mucocutaneous HSV infections

A

Cidofovir

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6
Q

Used in HSV infection in patients with AIDS

A

Foscarnet

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7
Q

NNRTIs

A

Never ever deliver nucleosides
Nevirapine
Efavirenz
Delavirdine

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8
Q

Used for the prevention of maternal-fetal HIV transmission

A 
NRTIs:
Zidovudine
Lamivudine
Tenofovir
Didanosine
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9
Q

Inhibits HIV reverse transcriptase after phosphorylation by cellular enzymes

A

NRTIs

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10
Q

Inhibits HIV reverse transcriptase without phosphorylation

A

NNRTIs

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11
Q

NRTI which causes bone marrow suppression

A

Zidovudine

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12
Q

NRTI which causes pancreatitis

A

Didanosine

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13
Q

NRTI which causes peripheral neuropathy

A

Stavudine

Zalcitabine

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14
Q

NNRTIs which causes increased AST/ALT

A

Delavirdine

Nevirapine

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15
Q

NNRTIs which is teratogenic

A

Efavirenz

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16
Q

NNRTIs which causes increased cholesterol and TG

A

Etravirine

17
Q

Protease inhibitor

A

-navir

Indinavir

18
Q

Causes hyperbilirubinemia and nephrolithiasis

A

Indinavir

19
Q

Causes GI distress and diarrhea

A

Saquinavir

20
Q

Fusion inhibitor; binds to gp41 subunit preventing fusion of viral and cellular membranes

A

Enfuvirtide

21
Q

CCR5 receptor antagonist; blocks viral attachment

A

Maraviroc

22
Q

Used in influenza A only

A

Amantadine (prevents uncoating)

23
Q

Causes cerebellar dysfunction and livedo reticularis

A

Amantadine

24
Q

MOA of oseltamivir and zanamivir

A

Inhibits neuraminidase; decreases release of progeny virus

25
Q

Causes bronchospasm in asthmatics

A

Zanamivir

26
Q

DOC for influenza (including H1N1)

A

Oseltamivir

27
Q

Used in HBV infection, HCV infection, and kaposi sarcoma

A

Interferon alpha

28
Q

MOA of Lamivudine

A

Inhibits HBV DNA polymerase

29
Q

Used in HBV and HIV infection

A

Lamivudine

30
Q

MOA of ribavirin

A

Inhibits guanosine triphosphate formation

31
Q

Used in HCV and RSV infection

A

Ribavirin

32
Q

MOA of acyclovir

A

Activated by viral thymidine kinase (TK) to forms that inhibit viral DNA polymerase

Pharmacology (31 decks)

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