T4: Lecture 3 Flashcards
What is the diagnostic criteria for Major Depressive Episode (MDE)?
- FIVE or more of the following in a TWO WEEK PERIOD
- Must include depressed mood OR loss of interest
1. depressed mood most of the day
2. diminished interest/pleasure in most activities
3. significant weight loss/gain (>5% change)
4. insomnia or hypersomnia
5. psychomotor agitation retardation (difficulty controlling energy levels)
6. Fatigue or loss of energy
7. Feelings of worthlessness/excessive guilt
8. Diminished ability to think/concentrate, indecisive
9. Recurrent thoughts of death/suicidal ideation/plan/attempt
-Cannot be due to substance/medical condition
What are the two depressive disorders in the DSM-5?
- Major Depressive Disorder (MDD)
2. Persistent Depressive Disorder (Dysthymia)
What is the prevalence of these disorders?
- Common
- MDD more likely in women than men
- In PDD the gender difference isn’t as big
- No difference between Maori and Pakeha
What are the two Biochemical factors in depression?
- Neurotransmitters (receptor sensitivity)
2. Hormones (dysregulation)
What is norepinephrine linked to?
To energy and reward seeking
What is serotonin linked to?
To mood, memory, concentration, sleep
What is dopamine linked to?
To rewarding stimuli, pleasure seeking
(hormones) what is hypothalamic-pituitary-adrenal (HPA) axis linked to?
Stress
What is the pathway of interpreting and reacting to stress in the brain?
Stressor->amygdala (perceives stress) ->HPA ->Cortisol
What are the three brain abnormalities associated with depression?
- Emotions projecting into the prefrontal cortex
- Emotional regulation system
- Left frontal hemisphere Asymmetry
Where does the limbic system project into?
The prefrontal cortex
-Seritonergic pathway
What are the four emotional regulation systems?
- Amygdala (emotional importance)
- Subgenual anterior cingulate (emotional regulation)
- Dorsolateral prefrontal cortex (emotional regulation)
- Hippocampus ( emotional regulation)
What happens in Left Frontal Hemisphere Asymmetry?
The right side of the frontal lobe is more activated than the left
-The left side is associated with positive thought and relaxation
What is life stress?
Stress is the relationship between a person and environment thats APPRAISED by the person as taking/exceeding resources, or endangering their well being
What is the Diathesis-Stress model?
That it’s not just stress, but also individuals are more biologically vulnerable