Synaptic integration

Question 1

temporal summation

Answer 1

ESPSPs or IPSPs from the same synapse occurs close enough in time to sum

Question 2

spatial summation

Answer 2

EPSPs and/or IPSPs from different synapses occur close enough in time to sum (have to arrive at the same physical space at the same time)

Question 3

the conduction of PSPs down dendrites

Answer 3

degrade as they travel (AP down axon do not degrade)

Question 4

rate of degradation of PSPs

Answer 4

depends on distance of the synapse from the soma, dendritic membrane resistance (increase resistance, less ion movement, less decay), and dendritic diameter (larger diameter, less internal resistance, less decay) NOTE: dendritic diameter is not constant (thin at end, thick close to soma)

Question 5

shunting

Answer 5

inhibitory signal allows Cl- to flow into the dendrite and negate an EPSP; can measure IPSP in the presence of EPSP, by changing Cl- concentration or by changing the concentration of Na+ and K+ to change the membrane potential and trigger a driving force

Question 6

modulation by metamorphic receptors

Answer 6

cascade diffuses out and spreads globally (not just local signal opens), lasts longer, has more widespread effects