stable coronary artery disease Flashcards

1
Q

what percent of the ciruclatrion ins the heart is microcirculation

A

70%

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2
Q

what is coronary artery diseae

A

angina and mi

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3
Q

what is stable atypical angina sympotns

A

breathlessness without cest pain, burn/ refulx/ burpig

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4
Q

main gender effected by angia

A

males

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5
Q

what are the determines of heart demand for blood to heart iee. when does the heart use up more 02

A

heart reaet
systolic blood pressure
myocardil wlal stress
myocardil contraciles

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6
Q

what are the determeis of heart supley ie when does the heart reci e less o2

A

coronary heart diames
collateral blood flow
perfusion pressure
heart

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7
Q

what ist he order for treating stable coraonery artyr dise

A

1 - relive sympons by reducing worklo and improin flow
2- halt/ slow disease
3 - prevent mi
4 - prevent premature death

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8
Q

what are the pharmacotherapy rate limitins drugs

A

beat adrenoreceptor antagonists
calcium channel blockers
ivabradine channels

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9
Q

what are the vaso dilator drugs

A

nitrates - e.g. nitric oxide
calciium channel blockers
potassium channel activators

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10
Q

what are exampesl of sodium chanel activators

A

ranolazine

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11
Q

what are examplesof antiplatelets

A

aspirin, clopidogrel, ticagrelor prasugrel

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12
Q

what are some exaples of cholesetor lowering drugs

A

hmg- coa reductas inhibitors
fibrates
pcsk- 9 inhibitors

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13
Q

examples of cardio selctive betal blocker

A

bisoprolol, metoprolo - short acting
atenolol

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14
Q

what are some examples of non selective beta blockers

A

carvedilol, propranolol

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15
Q

what are some side effects of beta blokcer

A

asthma, periperva vasucalr disaer, raynaulds syndorem, acute herat faiule, bradycarida, fatique

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16
Q

what is the effect of beta antangoins on systolic wall tneoin

A

reduced, thus more relaxed

17
Q

what are rate liming calcium channel blokcer caled

A

non diphyropyridine

18
Q

what aer the moslt vasodilating calcium channel blocekrs called

A

dihyropyridine

19
Q

exampels of non dihydropyridine calcium chanel blocker

A

amlodipine, felodipine, nifedipine

20
Q

what are examples of some dihydropyridine calcium channel blocker

A

verapamil
dilitazem

21
Q

what are side effects of calcium channel blocker

A

bradycardia, reduced lv fuction, headaches, flusihg, preipheal odema, hypotension

22
Q

wha are potasium vaso dilators exMPELS

A

NICRORANDIL

23
Q

WHAT ARE THE SIDE EFFECTS OF NICORANDIL

A

GI ulcers, hypotension

24
Q

how do postiaium chennl activtor work

A

inhibi claium influx thus caus vasodilators

25
What heart rate do funncy chnel inhibirots wok on
sinus heart rate
26
what is a funny channel inhibitor example
ivabradine
27
what is the side effects of ivabradin
bradycarida, sa node diase
28
what are some thromboxane a2 inhibots work on
txa2 pathway by prevent the sytehis of cox and plteulet activation
29
what does theinioprides work on
p2y12 recectors
30
what are exapesl of p2y12 inhitors
clopidogrel, ticagreol, prasugrel
31
what re exaples of thromboaxan a2 ihibotrs
aspirin
32
what is the effect of ranolazine
late sodium chanel inhibort in myocadiul cells, thu ibhore radi phase of delated calcium reducin interacelluar alium
33
what s the side effects of ranolazine
prologned qtc - wave
34
what drug should soium channle blocker be avoided using with
cyp enzyme inbibtitos
35