CVS Physiology 9 Flashcards

1
Q

what organ is makly resonisble for the long term control of blood pressure

A

kidneys

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2
Q

what are some functions of the kidenys

A

exertion of waste
maintenace of ion balace
regulation of ph
regulation of osmolarity
reguatoon of plasma volume

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3
Q

what specil part of blood is used to measure map

A

plasma volume

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4
Q

what is the osmoliarty outside the collecting duct

A

very high

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5
Q

what moluece determies the osmolarity gradient in the kidnes

A

na

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6
Q

at what point inthe loop of henie is the concentration of sodium the greateest

A

bottom, due to gravity

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7
Q

what happens if the colletin duct is very water permeable

A

lots of water reabosbrion and little urine produced which conserves plasma volume

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8
Q

what happens if you make htte collecting duct impermeable to water

A

very little reabsorbtion will occur and thus there will be lots of urine and a reduction in plasma volume

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9
Q

what is the renin angiotnsin sterone systme

A

The renin–angiotensin system (RAS), or renin–angiotensin–aldosterone system (RAAS), is a hormone system that regulates blood pressure, fluid and electrolyte balance, and systemic vascular resistance.

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10
Q

where is renis prodiued

A

fro hte juxtaglomerular cells of the kidney (granule cell)

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11
Q

what trigger renein production

A

sympathiect nerves to juxtaglomerular apparatus ( redeuces map
decreadsed distention of the afferent arterioles
decreased delivery of na+/cl-

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12
Q

what is the general effect of renin productoin

A

increase in map

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13
Q

what does renin do

A

converts inactive angiotensinogen to angiotensin 1

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14
Q

what convertes angiotension 1 into angiotension 2

A

angiotensin converting enzyme

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15
Q

what does angiotensin 2 do

A

stimulates the relase of aldrosterone fromthe adreal cortex
stimulares the release of adh
vasco constivtor

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16
Q

what is the fucntion of aldosterone

A

increases na+ reabsorption in the loop of henle
reduces diuresis and increases plasma volume

17
Q

where is adh relased from

A

piturity gland

18
Q

wher is adh symptestied

A

hypothalamus

19
Q

what is the function of adh

A

increases water perijmty to the colllecting duct - increasing plama volume
vascocontriton - increase map
increases sensation of thirst

20
Q

what is the effect of vascocontrictor on the tpr

A

increases it

21
Q

what cuaes hte relaes in adh

A

decre in blood volume - from the cardiopulmonary barocrectpotrs - via delayed meullary cariovascarul centers
an increase in osmolarity of the interstital fluid
circulation angiotension 2

22
Q

anp

A

atrial natriuretic peptide

23
Q

bnp

A

brain natriuretic peptide

24
Q

where is anp and bnp produces

A

myocardia cells in the atria and venticules

25
Q

what triggers the relase of anp and bnp

A

increasded distension of the artia and venticeles

26
Q

what do anp and bnp do

A

increse excertio of na+
inhibit the realse of renin
act onmedullary cv centres to reduces map

27
Q

what percent of hypertension are secondary

A

5-10 %

28
Q

what drug basis treamet can be used

A

ca2+ channel antagoinis
b - adrenoreceptor antagaonists
thiazide diuretics
angiotension converting enzyme inhibitors
angiotensin 2 antagonists

29
Q

what is teh role of adh

A

increase senstion of first, vasoconstior
incrase periml yof collecting duct to h20

30
Q

where is adh from

A

pitarury gland

31
Q

where is adh sympteised

A

hypothalamus

32
Q

what isthe role of aldosterone

A

incrases na reaposionin te loop of henle
reduces diures and increase palsam voues

33
Q

what isthe treiggers for adh

A

baro recorprs
incrased osmolaity of intersi fludi by osmorecoprots in the hypothalums
circulating angiotensin 2

34
Q

what triggers teh reales of aldosteron

A

alterotensin 2

35
Q

role of anp and bnp

A

increase eeertio of na
inhib rnels of rening
act on meuarl to cv centre to reedd map